SynthesisForensic science, medicine, and pathology2020
Diagnostic role of postmortem CK-MB in cardiac death: a systematic review and meta-analysis.
Synthesis in Forensic science, medicine, and pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Del Nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials.Journal of cardiothoracic surgery · 2024Pooled it
- Structural and morphological modulation of the myocardium byBiochemistry and biophysics reports · 2026Article
- Risk factors for sudden cardiac death or sudden unexplained death in patients treated with clozapine: systematic review.BJPsych open · 2026Review
- Aerobic Exercise under Cold Conditions May Affect the Cardiac Structure by Elevating the Galectin 3 and CK-MB Levels.Journal of human kinetics · 2026Article
- Observational
- Assessment of cardiac biomarker "point-of-care" testing as postmortem diagnostic tool.International journal of legal medicine · 2025Article
- Quantification of Myocardial Biomarkers in Sudden Cardiac Deaths Using a Rapid Immunofluorescence Method for Simultaneous Biomarker Analysis.Biomedicines · 2025Article
- A preliminary study on physiological dynamism of various serum cardiac biomarkers in apparently healthy Sipli sheep of Pakistan.Open veterinary journal · 2025Article
- Comparison of the effect of cardioplegic solutions used in cardiac surgery on myocardial protection.Revista da Associacao Medica Brasileira (1992) · 2025Article
- NSE and S100β as serum alarmins in predicting neurological outcomes after cardiac arrest.Scientific reports · 2024Observational
- Postmortem biochemical analysis of soluble ST2 in the pericardial fluid of patients with sudden cardiac death caused by ischemic heart disease: a pilot study.Forensic science, medicine, and pathology · 2024Article
- Evaluation of Biochemical Characteristics in a Retrospective Cohort of COVID-19 Patients.Cureus · 2024Article
- Beneficial role of amygdalin extracts against animal growth regulator Boldjan induced cardiac toxicity, injury and oxidative stress in male rats.Toxicology research · 2024Article
- V-A ECMO for neonatal coxsackievirus B fulminant myocarditis: a case report and literature review.Frontiers in cardiovascular medicine · 2024Article
- Phenolics Extracted fromMolecules (Basel, Switzerland) · 2023Article
- Forensic identification of sudden cardiac death: a new approach combining metabolomics and machine learning.Analytical and bioanalytical chemistry · 2023Article
- The enzymes in COVID-19: A review.Biochimie · 2022Review
- Elevated Myoglobin in Patients With Primary Aldosteronism: A Cross-Sectional Study.Frontiers in endocrinology · 2022Article
- Cardioprotective action of aprepitant in a rat model of ischemia-reperfusioninduced myocardial injury: role of PI3K-AkT-GSK-3β-HIF-1α signaling pathway.Acta cirurgica brasileira · 2022Article
- Endoplasmic reticulum stress-related secretory proteins as biomarkers of early myocardial ischemia-induced sudden cardiac deaths.International journal of legal medicine · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Biochemical analysis of creatine kinase MB (CK-MB), which is a biomarker of myocardial damage, is used as a potential adjunct test in clinical and forensic medicine. However, there is no previous meta-analysis that summarizes the diagnostic value of postmortem biochemical analysis of CK-MB in cardiac death. The purpose of this study was to perform a systematic literature review and meta-analysis of postmortem CK-MB in cardiac death for forensic work. Six online databases, including PubMed, Embase, Cochrane Library, the China National Knowledge Infrastructure (CNKI), the China Biomedical Literature Database (CBM), and Wanfang Data, were used to search for related studies. The quality of the included literature was assessed according to the Newcastle-Ottawa Quality Assessment Scale (NOS). The meta-analysis was performed by Review Manager version 5.3 software to investigate the diagnostic role of postmortem CK-MB in cardiac death, especially in myocardial infarction. Sixteen pieces of related literature were identified, all of which were considered high quality. The results of the meta-analysis revealed that the postmortem CK-MB level in the pericardial fluid was significantly higher in the cardiac death group with a standard mean difference (SMD) = 0.63, 95% confidence interval (CI) = 0.09~1.17, p = 0.02. This was also the result in the myocardial infarction group (SMD = 0.83, 95% CI = 0.10~1.56, p = 0.03). No significant difference in CK-MB was found in serum for cardiac death (SMD = -0.31, 95% CI = -0.85~0.24, p = 0.27) or myocardial infarction (SMD = -0.10, 95% CI = -0.69~0.49, p = 0.74). The postmortem biochemical analysis of CK-MB in the pericardial fluid can be used as an auxiliary method in the postmortem diagnosis of cardiac death, along with autopsy and histological investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.