ArticleWorld journal of urology2021
The association between serum serotonin levels and overactive bladder: results from a community-based cross-sectional study in Japan.
Article in World journal of urology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Efficacy of salt reduction for managing overactive bladder symptoms: a prospective study in patients with excessive daily salt intake.Scientific reports · 2021Trial
- The Afferent Threshold Hypothesis: A Unified Neural Framework for Functional Bladder Capacity and Nocturia.International neurourology journal · 2026Article
- Psychosocial risk and protective factors for men's lower urinary tract symptoms: A secondary analysis of CARDIA cohort study data.Journal of health psychology · 2026Article
- Urothelial Proteome Changes Underlying Overactive Bladder Associated With Bladder Outlet Obstruction.International neurourology journal · 2025Article
- Cross-Sectional Associations of Depressive Symptoms, Anxiety Symptoms, and Emotional Support Seeking with Lower Urinary Tract Symptoms and Bladder Health.International urogynecology journal · 2025Article
- Serum Serotonin Levels as a Potential Risk Factor for Overactive Bladder in a Community-Dwelling Population: A Four-Year Longitudinal Study.Lower urinary tract symptoms · 2025Article
- Pathways from Adverse Childhood Family Environment to Lower Urinary Tract Symptoms and Impact Among Women.Journal of women's health (2002) · 2025Article
- Bidirectional relationships between depression, anxiety and urinary symptoms in women: A prospective cohort study.Journal of affective disorders · 2025Article
- Correlations between serotonin impairments and clinical indices in multiple system atrophy.European journal of neurology · 2024Article
- Discrimination and bladder health among women in the CARDIA cohort study: Life course and intersectionality perspectives.Social science & medicine (1982) · 2024Article
- Financial strain across 25 years and women's bladder health: a life course perspective.American journal of obstetrics and gynecology · 2024Article
- Activation of uroepithelial 5-HTFrontiers in physiology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo investigate the association between serum serotonin (5-HT) levels and overactive bladder (OAB) in a community-dwelling population.
methodsThis cross-sectional study analyzed 1024 subjects who participated in the Iwaki Health Promotion Project in 2015 in Hirosaki, Japan. OAB was assessed using the Overactive Bladder Symptom Score (OABSS). OAB was defined as an occurrence of urinary urgency at least once a week and an OABSS of ≥ 3. We assessed serum 5-HT levels, laboratory data, and comorbidities of each participants. Participants' mental health status was evaluated using the Center for Epidemiologic Studies Depression (CES-D) scale. The association of serum 5-HT levels and OAB was analyzed by multivariable logistic regression analysis.
resultsThis study included 394 men and 630 women. Of those, 118 (44 male and 74 female) were OAB sufferers. There were significant group differences in age, history of cardiovascular disease, chronic kidney disease, hypertension, diabetes mellitus, and CES-D score. Participants' serum 5-HT levels in the OAB group were significantly lower than those in the non-OAB group (100 vs. 127 ng/mL, P < 0.001). Multivariable analysis showed that age (odds ratio [OR]; 1.06, 95% confidence interval [CI]; 1.04-1.08, P < 0.001) and log serum 5-HT level (OR; 0.25, 95% CI; 0.10-0.68, P = 0.006) were independently associated with OAB.
conclusionsLower serum 5-HT levels could independently be associated with the presence of OAB. Further study is necessary to elucidate a possible causal relationship between serum 5-HT levels and OAB.
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