ArticleAdvances in nutrition (Bethesda, Md.)2020
Assessing the Evidence of Micronutrients on Depression among Children and Adolescents: An Evidence Gap Map.
Article in Advances in nutrition (Bethesda, Md.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- The Changes of Blood and CSF Ion Levels in Depressed Patients: a Systematic Review and Meta-analysis.Molecular neurobiology · 2024Pooled it
- Do Healthy Dietary Interventions Improve Pediatric Depressive Symptoms? A Systematic Review and Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2021Pooled it
- Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children.JAMA network open · 2026Article
- School-Based Weekly Iron-Folic Acid Supplementation and Its Effect on Mental Health Outcomes Among Adolescent Girls in Central Ethiopia: A Cluster-Randomized Controlled Trial.Journal of nutrition and metabolism · 2026Article
- Evidence for various interventions to reduce depressive symptoms for children and adolescents: protocol of a global evidence and gap map.Systematic reviews · 2025Article
- Evidence map of nutrient interventions for major depression: a systematic review protocol.Systematic reviews · 2025Article
- Impact of household food insecurity and nutrition on depression and anxiety symptoms among adolescents living in rural Pakistan.Global mental health (Cambridge, England) · 2025Article
- PROTOCOL: Treatment for depressive disorder among adults: An evidence and gap map of systematic reviews.Campbell systematic reviews · 2023Article
- Depressive symptoms among Mexican adolescent girls in relation to iron status, anaemia, body weight and pubertal status: results from a latent class analysis.Public health nutrition · 2023Article
- Article
- Environmental Influences on the Behavioural and Emotional Outcomes of Children: A Network Analysis.International journal of environmental research and public health · 2022Article
- Eating, sleeping and moving recommendations in clinical practice guidelines for paediatric depression: umbrella review.BJPsych open · 2021Review
- Assessing the Evidence of Micronutrients on Depression among Children and Adolescents: An Evidence Gap Map.Advances in nutrition (Bethesda, Md.) · 2020Article
- Lower serum selenium concentration associated with anxiety in children.Journal of pediatric nursingArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is some evidence indicating that nutrition may have the ability to prevent, treat, and/or influence the severity of depression. The aims of this evidence gap map (EGM) are to provide an overview and to determine evidence gaps in the existing research on micronutrients and their impact on depression among children and adolescents. We conducted a comprehensive search in multiple databases of primary and secondary literature assessing the impact of micronutrients on depression-related outcomes such as unipolar depression, major depressive disorders, dysthymia, acute depression, and mood disorders. Abstracts and full-text articles were dual-screened based on predefined eligibility criteria. A total of 30 primary research publications were included in the EGM. About 47% of included studies focused on late adolescents (15-19 y), ∼40% on early adolescents (10-14 y), and ∼13% on children aged 6-9 y. Among the included studies, 8 studies examined a single micronutrient intervention and 22 studies examined micronutrient concentrations (either intake or serum), and their impact on depression. The most frequently studied micronutrients were vitamin D (n = 8), zinc (n = 8), iron (n = 6), folate (n = 7), and vitamin B-12 (n = 5). More longitudinal studies and trials are needed to determine the role of micronutrients in the etiology and treatment of depression among children and adolescents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.