SynthesisCommunications biology2020
Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.
Open access · goldAbstract readMeta-Analysis
In one paragraph
Synthesis in Communications biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- GWAS for primary angle-closure glaucoma identifies loci related to ocular biometry and morphology.Nature communications · 2025Pooled it
- Effects of Physical Exercise Combined with Accommodative Training on Visual Acuity and Ocular Biometric Parameters in Children Aged 6-7.Life (Basel, Switzerland) · 2026Article
- Anisometropia and Its Related Traits: Ocular, Systemic, and Genetic Characteristics-Results From the Gutenberg Health Study.Investigative ophthalmology & visual science · 2026Article
- Advances in the genetics of refractive errors: Contributions from the CREAM consortium.Acta ophthalmologica · 2026Review
- Genetic associations of corneal astigmatism in Hong Kong Chinese children.Scientific reports · 2026Article
- Robust and interpretable unit level causal inference in neural networks for pediatric myopia.NPJ digital medicine · 2026Article
- Association between refraction characteristics and anthropometrics in 7- to 10-year-old Chinese primary school students.BMC ophthalmology · 2026Article
- Genome-wide association study of quantitative ocular traits, including axial length and central corneal thickness, identifies loci for refractive error in the Korean population.Genes & genomics · 2026Article
- Gene polymorphisms associated with corneal curvature, astigmatism and its vector components in children.Eye and vision (London, England) · 2025Article
- IMI-Myopia Genetics Report.Investigative ophthalmology & visual science · 2025Review
- Effect of repeated Low-Level red light therapy on axial length in myopic individuals: predictors for a good response.BMC ophthalmology · 2025Article
- Myopic Strain: a normalized metric concept for assessing axial myopia.Frontiers in ophthalmology · 2025Article
- Omega-3 Polyunsaturated Fatty Acids as a Protective Factor for Myopia.American journal of ophthalmology · 2024Article
- Bi-Gaussian analysis reveals distinct education-related alterations in spherical equivalent and axial length-results from the Gutenberg Health Study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Article
- A wireless battery-free eye modulation patch for high myopia therapy.Nature communications · 2024Article
- Distribution and correlation of refractive parameters in children with different corneal curvatures in southeast China.International journal of ophthalmology · 2024Article
- A multiethnic genome-wide analysis of 19,420 individuals identifies novel loci associated with axial length and shared genetic influences with refractive error and myopia.Frontiers in genetics · 2023Article
- ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.Communications biology · 2022Article
- Article
- Vision-related convergent gene losses revealeLife · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
60 authors at 20 institutions in 15 countries.
Qiao Fan *Centre for Quantitative Medicine, Duke-NUS Medical School, 20 College Road, 169856, Singapore, Singapore. qiao.fan@duke-nus.edu.sg.
Alfred Pozarickij *School of Optometry and Vision Sciences, Cardiff University, Cardiff, CF24 4HQ, UK.
Nicholas Y Q Tan *Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Xiaobo Guo *Department of Statistical Science, School of Mathematics, Sun Yat-Sen University, Guangzhou, China.
Virginie J M Verhoeven *Department of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0001-7359-7862
Veronique VitartMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-4991-3797
Jeremy A GuggenheimSchool of Optometry and Vision Sciences, Cardiff University, Cardiff, CF24 4HQ, UK.ORCID http://orcid.org/0000-0001-5164-340X
Masahiro MiyakeDepartment of Ophthalmology and Visual Sciences, Kyoto University, Kyoto, 6068507, Japan.
J Willem L TidemanDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Anthony P KhawajaNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.ORCID http://orcid.org/0000-0001-6802-8585
Liang ZhangOcular Epidemiology Research Group, Singapore Eye Research Institute, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9264-170X
Stuart MacGregorQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0001-6731-8142
René HöhnDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Peng ChenSaw Swee Hock School of Public Health, National University Health Systems, National University of Singapore, Singapore, Singapore.
Ginevra BiinoInstitute of Molecular Genetics, National Research Council of Italy, Pavia, 27100, Italy.
Juho WedenojaDepartment of Ophthalmology, University of Helsinki and Helsinki University Hospital, Helsinki, FI-00290, Finland.ORCID http://orcid.org/0000-0002-6155-0378
Seyed Ehsan SaffariCentre for Quantitative Medicine, Duke-NUS Medical School, 20 College Road, 169856, Singapore, Singapore.ORCID http://orcid.org/0000-0002-6473-4375
Milly S TedjaDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0356-9684
Jing XieOccupational and Environmental Health Sciences, School of Public Health and Preventative Medicine, Monash University, Melbourne, 3004, Australia.
Carla LancaMyopia Research Group, Singapore Eye Research Institute, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9918-787X
Ya Xing WangBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2749-7793
Srujana SahebjadaCentre for Eye Research Australia (CERA), University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, 3002, Australia.
Johanna MazurInstitute for Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Alireza MirshahiDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Australia.ORCID http://orcid.org/0000-0003-4069-8020
Seyhan YazarCentre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.
Craig E PennellSchool of Women's and Infants' Health, The University of Western Australia, Perth, WA, 6009, Australia.
Maurice YapSchool of Optometry, The Hong Kong Polytechnic University, Hong Kong SAR, China.ORCID http://orcid.org/0000-0003-4687-4101
Annechien E G HaarmanDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Clair A EnthovenDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
JanRoelof PollingDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Consortium for Refractive Error and Myopia (CREAM)
UK Biobank Eye and Vision Consortium
Alex W HewittCentre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.ORCID http://orcid.org/0000-0002-5123-5999
Vincent W V JaddoeGeneration R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.ORCID http://orcid.org/0000-0003-2939-0041
Cornelia M van DuijnDepartment of Epidemiology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.ORCID http://orcid.org/0000-0002-9405-9550
Ozren PolasekFaculty of Medicine, University of Split, Croatia, Split, 21000, Croatia.
E-Shyong TaiSaw Swee Hock School of Public Health, National University Health Systems, National University of Singapore, Singapore, Singapore.
Hosoda YoshikatsuDepartment of Ophthalmology and Visual Sciences, Kyoto University, Kyoto, 6068507, Japan.
Pirro G HysiSection of Academic Ophthalmology, School of Life Course Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5752-2510
Terri L YoungDepartment of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0001-6994-9941
Akitaka TsujikawaDepartment of Ophthalmology and Visual Sciences, Kyoto University, Kyoto, 6068507, Japan.
Jie Jing WangDuke-NUS Medical School, Singapore, Singapore.ORCID http://orcid.org/0000-0001-9491-4898
Paul MitchellCentre for Vision Research, Department of Ophthalmology and Westmead Institute for Medical Research, University of Sydney, Sydney, NSW, 2145, Australia.
Norbert PfeifferDepartment of Ophthalmology, University Medical Center of the Johannes Gutenberg-University Mainz, 55131, Mainz, Germany.ORCID http://orcid.org/0000-0002-5766-2617
Olavi PärssinenGerontology Research Center and Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FI-40100, Finland.
Paul J FosterNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, EC1V 2PD, UK.ORCID http://orcid.org/0000-0002-4755-177X
Maurizio FossarelloSan Giovanni di Dio hospital, Clinica Oculistica, Azienda Ospedaliera Universitaria di Cagliari, Cagliari, 09131, Italy.
Shea Ping YipDepartment of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong SAR, China.
Cathy WilliamsPopulation Health Sciences, Bristol Medical School, University of Bristol, Bristol, BS8 1NU, UK.
Christopher J HammondSection of Academic Ophthalmology, School of Life Course Sciences, King's College London, London, UK.ORCID http://orcid.org/0000-0002-3227-2620
Jost B JonasBeijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.ORCID http://orcid.org/0000-0003-2972-5227
Mingguang HeState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China.
David A MackeyCentre for Ophthalmology and Visual Science, University of Western Australia, Lions Eye Institute, Perth, Australia.
Tien-Yin WongOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Caroline C W KlaverDepartment of Ophthalmology, Erasmus Medical Center, 3000 CA, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2355-5258
Seang-Mei SawOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore.
Paul N BairdDepartment of Surgery, Ophthalmology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Royal Victorian Eye and Ear Hospital, Melbourne, 3002, Australia.ORCID http://orcid.org/0000-0002-1305-3502
Ching-Yu ChengOphthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. cheng.ching.yu@seri.com.sg.
UCL Biomedical Research Centre · GBNational Institutes of Health · USQueen's University Belfast · GBErasmus MC · NLCardiff University · GBJohannes Gutenberg University Mainz · DEUniversity of Edinburgh · GBUniversity of Southampton · GBKing's College London · GBMoorfields Eye Hospital NHS Foundation Trust · GBQIMR Berghofer Medical Research Institute · AUSingapore National Eye Center · SGUniversity of Wisconsin–Madison · USBeijing Tongren Hospital · CNCase Western Reserve University · USChinese University of Hong Kong · HKInstitute of Genetics and Cancer · GBKyoto University · JPLions Eye Institute · AUNational University of Singapore · SG
Funding
Genetic Epidemiology of Complex TraitsZIAHG200327 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BAILEY-WILSON, JOAN ELLEN · 2009 to 2022
$10.5MMedical Research Council MC_UU_00007/10Medical Research Council MR/T019050/1Medical Research Council MR/T040912/1
Abstract
Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major cause of visual impairment and blindness in the world. Here we present a trans-ethnic meta-analysis of corneal curvature GWAS in 44,042 individuals of Caucasian and Asian with replication in 88,218 UK Biobank data. We identified 47 loci (of which 26 are novel), with population-specific signals as well as shared signals across ethnicities. Some identified variants showed precise scaling in corneal curvature and eye elongation (i.e. axial length) to maintain eyes in emmetropia (i.e. HDAC11/FBLN2 rs2630445, RBP3 rs11204213); others exhibited association with myopia with little pleiotropic effects on eye elongation. Implicated genes are involved in extracellular matrix organization, developmental process for body and eye, connective tissue cartilage and glycosylation protein activities. Our study provides insights into population-specific novel genes for corneal curvature, and their pleiotropic effect in regulating eye size or conferring susceptibility to myopia.
Indexed as
Corneal TopographyGenetic LociPolymorphism, Single NucleotideAsian PeopleAxial Length, EyeCorneaDatabases, GeneticGene Regulatory NetworksGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMyopiaPhenotypeRefractometryRisk AssessmentRisk Factors
Identifiers
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.