Evidence map›Paper›PMID 32193439›Full record

ArticleScientific reports2020

Novel B cell-dependent multiple sclerosis model using extracellular domains of myelin proteolipid protein.

Alexander W Boyden, Ashley A Brate, Nitin J Karandikar

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexander W BoydenDepartment of Pathology, University of Iowa Health Care, Iowa City, IA, USA.
Ashley A BrateDepartment of Pathology, University of Iowa Health Care, Iowa City, IA, USA.
Nitin J KarandikarDepartment of Pathology, University of Iowa Health Care, Iowa City, IA, USA. nitin-karandikar@uiowa.edu.
Veterans Health Administration · USUniversity of Iowa Health Care · US

Funding

Immune Dysregulation During Multiple Sclerosis RelapseR01AI121567 · NIAID · UNIVERSITY OF IOWA · PI KARANDIKAR, NITIN J · 2016 to 2020
$3.8M
Immunotherapeutic Regulatory CD8 T cells in Autoimmune Demyelinating DiseaseI01BX003677 · VA · IOWA CITY VA MEDICAL CENTER · PI KARANDIKAR, NITIN J · 2017 to 2025
–
BLRD VA I01 BX003677NIAID NIH HHS R01 AI121567
6 · The paper itself

Abstract

Therapeutic success of B cell-targeting approaches in multiple sclerosis (MS) has intensified research into the pathogenic and regulatory roles these cells play in demyelinating disease. Dissecting the function of B cells in the MS mouse model experimental autoimmune encephalomyelitis (EAE) is largely confined to induction with either the myelin oligodendrocyte glycoprotein epitope MOG

Indexed as

Disease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalMultiple SclerosisMyelin-Oligodendrocyte GlycoproteinAnimalsB-LymphocytesEpitopesMice, Inbred C57BLMyelin Proteolipid ProteinPeptide FragmentsProtein DomainsEpitopesMog protein, mouseMyelin-Oligodendrocyte GlycoproteinMyelin Proteolipid Proteinmyelin proteolipid protein (178-191)Peptide Fragments

Identifiers

PMID32193439
PMCPMC7081236
OpenAlexW3010763064

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.