Evidence map›Paper›PMID 32193437›Full record

ArticleScientific reports2020

Longitudinal phenotype development in a minipig model of neurofibromatosis type 1.

Johanna Uthoff, Jared Larson, Takashi S Sato, Emily Hammond, Kimberly E Schroeder, Frank Rohret, Christopher S Rogers, Dawn E Quelle, Benjamin W Darbro, Rajesh Khanna and 3 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. NF1Clinical and translational science · 2024
    Article
  6. Review
  7. Article
  8. A Novel Porcine Model of CLN2 Batten Disease that Recapitulates Patient Phenotypes.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
    Article
  9. Review
  10. Spontaneous and Engineered Large Animal Models of Neurofibromatosis Type 1.International journal of molecular sciences · 2021
    Review
  11. An executive functioning perspective in neurofibromatosis type 1: from ADHD and autism spectrum disorder to research domains.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Johanna UthoffDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Jared LarsonDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Takashi S SatoDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Emily HammondDepartment of Radiology, University of Iowa, Iowa City, IA, USA.
Kimberly E SchroederDepartment of Biomedical Engineering, University of Iowa, Iowa City, IA, USA.
Frank RohretExemplar Genetics, Coralville, IA, USA.
Christopher S RogersExemplar Genetics, Coralville, IA, USA.
Dawn E QuelleHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Benjamin W DarbroHolden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA.
Rajesh KhannaDepartment of Pharmacology, University of Arizona, Tucson, AZ, USA.
Jill M WeimerPediatrics and Rare Diseases Group, Sanford Research, Sioux Falls, SD, USA.
David K MeyerholzDepartment of Pathology, University of Iowa, Iowa City, IA, USA.
Jessica C SierenDepartment of Radiology, University of Iowa, Iowa City, IA, USA. jessica-sieren@uiowa.edu.
University of Iowa · USExemplar Genetics (United States) · USSanford Research · USUniversity of Arizona · US

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Christopher K Laubenthal · 2000 to 2026
$70.0M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Ultra-low Dose, High Speed, High Resolution, Multispectral, Multi-Source MDCT ScaS10OD018526 · OD · UNIVERSITY OF IOWA · PI HOFFMAN, ERIC ALFRED · 2015 to 2015
$2.0M
NCI NIH HHS P30 CA086862NIEHS NIH HHS P30 ES005605NIH HHS S10 OD018526
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is a rare, autosomal dominant disease with variable clinical presentations. Large animal models are useful to help dissect molecular mechanisms, determine relevant biomarkers, and develop effective therapeutics. Here, we studied a NF1 minipig model (NF1

Indexed as

Disease Models, AnimalPhenotypeAnimalsDisease ProgressionHumansMagnetic Resonance ImagingNeurofibromaNeurofibromatosis 1SwineSwine, MiniatureTibiaTime FactorsTomography, X-Ray ComputedTranslational Research, Biomedical

Identifiers

PMID32193437
PMCPMC7081358
OpenAlexW3012195267

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.