ArticleScientific reports2020
Specific functions for Mediator complex subunits from different modules in the transcriptional response of Arabidopsis thaliana to abiotic stress.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 46 citations in OpenAlex.
- Integrated Phylogenomics and Expression Profiling of the MED Gene Family inPlants (Basel, Switzerland) · 2026Article
- Principles and mechanisms of plant acclimation to heat stress.Nature reviews. Molecular cell biology · 2026Review
- A phosphatidic acid-based retrograde signaling pathway responsive to abiotic stress in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- Adaptive Potential and Genomic Vulnerability of Keystone Forest Tree Species to Climate Change: A Case Study in Scots Pine.Evolutionary applications · 2025Article
- Molecular signatures of adaptive introgression and selection in contact zones of closely related pine species (Pinus genus).BMC plant biology · 2025Article
- Metabolism in Sync: The Circadian Clock, a Central Hub for Light-Driven Chloroplastic and Mitochondrial Entrainment.Plants (Basel, Switzerland) · 2025Review
- DSK2-mediated degradation of F-box protein LAO1 and class I TCPs modulates the nitrogen starvation response.EMBO reports · 2025Article
- Genome-Wide Identification and Expression Analysis of the Mediator Complex Subunit Gene Family in Cassava.International journal of molecular sciences · 2025Article
- The role of mediator subunit MED7 in Arabidopsis development.Frontiers in plant science · 2025Article
- RhMED15a-like, a subunit of the Mediator complex, is involved in the drought stress response in Rosa hybrida.BMC plant biology · 2024Article
- Pseudomonas syringae infectivity correlates to altered transcript and metabolite levels of Arabidopsis mediator mutants.Scientific reports · 2024Article
- Familial Dilated Cardiomyopathy: A Novel MED9 Short Isoform Identification.International journal of molecular sciences · 2024Article
- Comparative phylogenetic analysis of the mediator complex subunit in asparagus bean (Vigna unguiculata ssp. sesquipedialis) and its expression profile under cold stress.BMC genomics · 2024Article
- The Mediator kinase module enhances polymerase activity to regulate transcriptional memory after heat stress in Arabidopsis.The EMBO journal · 2024Article
- A new model construction based on the knowledge graph for mining elite polyphenotype genes in crops.Frontiers in plant science · 2024Article
- Long read sequencing to reveal the full complexity of a plant transcriptome by targeting both standard and long workflows.Plant methods · 2023Article
- The Essentials on microRNA-Encoded Peptides from Plants to Animals.Biomolecules · 2023Review
- The transcription factor TaMYB31 regulates the benzoxazinoid biosynthetic pathway in wheat.Journal of experimental botany · 2022Article
- The intersection between circadian and heat-responsive regulatory networks controls plant responses to increasing temperatures.Biochemical Society transactions · 2022Review
- The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses.The Plant cell · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adverse environmental conditions are detrimental to plant growth and development. Acclimation to abiotic stress conditions involves activation of signaling pathways which often results in changes in gene expression via networks of transcription factors (TFs). Mediator is a highly conserved co-regulator complex and an essential component of the transcriptional machinery in eukaryotes. Some Mediator subunits have been implicated in stress-responsive signaling pathways; however, much remains unknown regarding the role of plant Mediator in abiotic stress responses. Here, we use RNA-seq to analyze the transcriptional response of Arabidopsis thaliana to heat, cold and salt stress conditions. We identify a set of common abiotic stress regulons and describe the sequential and combinatorial nature of TFs involved in their transcriptional regulation. Furthermore, we identify stress-specific roles for the Mediator subunits MED9, MED16, MED18 and CDK8, and putative TFs connecting them to different stress signaling pathways. Our data also indicate different modes of action for subunits or modules of Mediator at the same gene loci, including a co-repressor function for MED16 prior to stress. These results illuminate a poorly understood but important player in the transcriptional response of plants to abiotic stress and identify target genes and mechanisms as a prelude to further biochemical characterization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.