ArticleNature communications2020
Olfactory specificity regulates lipid metabolism through neuroendocrine signaling in Caenorhabditis elegans.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 86 citations in OpenAlex.
- CXCR2-mediated metabolic interaction between prostate cancer cells and the immunosuppressive tumor microenvironment.Journal for immunotherapy of cancer · 2026Article
- A lipid-sensitive food choice behavior influences aging outcomes from a longevity-promoting diet.The FEBS journal · 2026Article
- A nose-to-brain axis for spoiled food odor-triggered defensive responses in male mice.Nature communications · 2026Article
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
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- SRS microscopy identifies inhibition of vitellogenesis as a mediator of lifespan extension by caloric restriction inbioRxiv : the preprint server for biology · 2025Article
- Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior.Genetics · 2024Review
- Hunger signalling in the olfactory bulb primes exploration, food-seeking and peripheral metabolism.Molecular metabolism · 2024Article
- Olfaction regulates peripheral mitophagy and mitochondrial function.Science advances · 2024Article
- Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity.eLife · 2024Article
- Exposure to an aversive odor altersmicroPublication biology · 2024Article
- RAL-1 signaling regulates lipid composition inmicroPublication biology · 2024Article
- Dissecting the genetic landscape of GPCR signaling through phenotypic profiling in C. elegans.Nature communications · 2023Article
- Stimulated Raman Scattering Imaging Sheds New Light on Lipid Droplet Biology.The journal of physical chemistry. B · 2023Article
- Odor Discrimination by Lipid Membranes.Membranes · 2023Article
- Application ofInternational journal of molecular sciences · 2023Review
- Culturomic-, metagenomic-, and transcriptomic-based characterization of commensal lactic acid bacteria isolated from domestic dogs using Caenorhabditis elegans as a model for aging.Journal of animal science · 2022Article
- Food odor perception promotes systemic lipid utilization.Nature metabolism · 2022Article
- Thermosensation in Caenorhabditis elegans is linked to ubiquitin-dependent protein turnover via insulin and calcineurin signalling.Nature communications · 2022Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Olfactory and metabolic dysfunctions are intertwined phenomena associated with obesity and neurodegenerative diseases; yet how mechanistically olfaction regulates metabolic homeostasis remains unclear. Specificity of olfactory perception integrates diverse environmental odors and olfactory neurons expressing different receptors. Here, we report that specific but not all olfactory neurons actively regulate fat metabolism without affecting eating behaviors in Caenorhabditis elegans, and identified specific odors that reduce fat mobilization via inhibiting these neurons. Optogenetic activation or inhibition of the responsible olfactory neural circuit promotes the loss or gain of fat storage, respectively. Furthermore, we discovered that FLP-1 neuropeptide released from this olfactory neural circuit signals through peripheral NPR-4/neuropeptide receptor, SGK-1/serum- and glucocorticoid-inducible kinase, and specific isoforms of DAF-16/FOXO transcription factor to regulate fat storage. Our work reveals molecular mechanisms underlying olfactory regulation of fat metabolism, and suggests the association between olfactory perception specificity of each individual and his/her susceptibility to the development of obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.