ArticleScience (New York, N.Y.)2020
Endoplasmic reticulum-associated degradation regulates mitochondrial dynamics in brown adipocytes.
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Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.
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136citing papers in PubMed
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136 citing papers in PubMed, 219 citations in OpenAlex.
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- GRP75 chaperone-driven mitochondria-ER membrane coupling promotes CaThe Journal of biological chemistry · 2026Article
- Spatiotemporal analysis of reactive oxygen species using specific activity-based sensing fluorescent imaging probes.Nature reviews. Chemistry · 2026Review
- Redox control at the ER-mitochondria interface in kidney transplantation: MAM-centered stress signaling and translational organoid platforms.Redox biology · 2026Review
- Emerging perspectives in proteostasis: bridging mechanisms and therapeutics for human diseases.Signal transduction and targeted therapy · 2026Review
- Crosstalk between endoplasmic reticulum stress and mitochondrial homeostasis: A new perspective on ophthalmic disease treatment.Journal of cell communication and signaling · 2026Review
- Transplantation of AQP1-overexpressing mitochondria attenuates periodontitis-associated bone loss by regulating mitochondria-ER contacts of macrophages.Journal of nanobiotechnology · 2026Article
- The Role of Sigmar1 in Autophagy Regulation and Disease Therapy.International journal of molecular sciences · 2026Review
- Functional rescue of a disease-linked ERAD pathway mutation via alternative splicing.The EMBO journal · 2026Article
- Neuronal SEL1L-HRD1 ER-associated degradation is essential for motor function and survival in mice.The Journal of clinical investigation · 2026Article
- SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- CabioRxiv : the preprint server for biology · 2026Article
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- Microsporidian Encephalitozoon hellem inhibits host mitophagy by inducing ERAD to degrade BNIP3L.PLoS pathogens · 2026Article
- Endoplasmic Reticulum Stress Induced by Turbulence of Mitochondrial Fusion and Fission Was Involved in Isoproterenol-Induced H9c2 Cell Injury.International journal of molecular sciences · 2026Article
- Structural basis and pathological implications of the dimeric OS9-SEL1L-HRD1 ERAD Core Complex.Nature communications · 2026Article
- Limiting ER-associated degradation capacity triggers acute and chronic effects on insulin biosynthesis.The Journal of clinical investigation · 2026Article
- Integrated analysis of RNA expression profiles and regulatory networks in porcine liver in response to cold stress.BMC genomics · 2026Article
- Loss of SEL1L or Hrd1 increases intrinsic LOX levels in HEK293 cells independently of proteasomal degradation.Molecular biology reports · 2026Article
76 more citing papers are in PubMed but not listed here.
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Authors and funding
20 authors at 5 institutions in 2 countries.
Zhangsen ZhouDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0001-7333-4624
Mauricio TorresDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0002-5081-9044
Haibo ShaDivision of Nutritional Sciences, Cornell University, Ithaca, NY 14850, USA.
Christopher J HalbrookDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0002-3376-3114
Françoise Van den BerghDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0003-4025-6863
Rachel B ReinertDepartment of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0001-7778-4219
Tatsuya YamadaDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Siwen WangDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0001-8927-4937
Yingying LuoDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0002-6391-4489
Allen H HunterCollege of Engineering and Michigan Center for Materials Characterization, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-1489-9809
Chunqing WangDepartment of Biochemistry and Molecular Biology and Autophagy, Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0002-2811-7230
Thomas H SandersonDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0003-0112-8164
Meilian LiuDepartment of Biochemistry and Molecular Biology and Autophagy, Inflammation and Metabolism Center for Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA.ORCID 0000-0003-1639-262X
Aaron TaylorBiomedical Research Core Facilities, University of Michigan, Ann Arbor, MI 48109, USA.ORCID 0000-0002-4192-2453
Hiromi SesakiDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0001-9309-6141
Jun WuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.
Sander KerstenNutrition, Metabolism and Genomics group, Wageningen University, Wageningen, Netherlands.
Daniel A BeardDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA.ORCID 0000-0003-0974-2353
Ling QiDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI 48105, USA. lingq@med.umich.edu.ORCID 0000-0001-8229-0184
University of Michigan · USJohns Hopkins University · USUniversity of New Mexico · USCornell University · USWageningen University & Research · NL
Funding
Michigan Institute for Clinical and Health Research (MCHR)UL1TR000433 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER · 2012 to 2016
$49.9MUnfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9MUniversity of Michigan Center for Gastrointestinal ResearchP30DK034933 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI OMARY, BISHR · 1986 to 2021
$22.5MPilot and Feasibility (P and F) ProgramP30DK089503 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kanakadurga Singer · 2010 to 2026
$20.3MStatistics and Bioinformatics Core - WangU24DK097153 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BURANT, CHARLES F · 2012 to 2017
$10.1MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MNovel Role of Hepatic SEL1L-HRD1 ERAD in FGF21 Gene TranscriptionR01DK120330 · NIDDK · UNIVERSITY OF VIRGINIA · PI Deyu Fang, Ling Qi · 2018 to 2026
$4.9MThe role of immune-adipocyte cholinergic signaling during metabolic adaptation and dysfunctionR01DK107583 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WU, JUN · 2016 to 2024
$3.4MRegulation of Mitochondrial Dynamics by ERAD: Administrative SupplementR35GM130292 · NIGMS · UNIVERSITY OF VIRGINIA · PI QI, LING · 2019 to 2023
$2.5MThe Role of Adiponectin in Regulating Group 2 Innate Lymphoid Cells and Browning in FatR01DK110439 · NIDDK · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LIU, MEILIAN · 2017 to 2021
$1.8MComputational systems analysis of cardiac mechanical-energetic coupling in heart diseaseR01HL144657 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BEARD, DANIEL A · 2019 to 2022
$1.8MMitochondrial Integrity Regulates Cerebral Reperfusion InjuryR01NS076715 · NINDS · WAYNE STATE UNIVERSITY · PI KUMAR, RITA, SANDERSON, THOMAS HUDSON · 2013 to 2017
$1.7MNCATS NIH HHS UL1 TR000433NCI NIH HHS F32 CA228328NCI NIH HHS K99 CA241357NCI NIH HHS L30 CA231806NHLBI NIH HHS R01 HL144657NIAMS NIH HHS P30 AR069620NIDDK NIH HHS P30 DK034933NIDDK NIH HHS P30 DK089503NIDDK NIH HHS R01 DK105393NIDDK NIH HHS R01 DK107583NIDDK NIH HHS R01 DK110439NIDDK NIH HHS R01 DK120047NIDDK NIH HHS R01 DK120330NIDDK NIH HHS U24 DK097153NIGMS NIH HHS P20 GM121176NIGMS NIH HHS R01 GM113188NIGMS NIH HHS R01 GM123266NIGMS NIH HHS R01 GM130695NIGMS NIH HHS R35 GM130292NINDS NIH HHS R01 NS038619NINDS NIH HHS R01 NS076715NINDS NIH HHS R01 NS091242
Abstract
The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic "megamitochondria" with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD.
Indexed as
Mitochondrial DynamicsAdipocytes, BrownAnimalsCold TemperatureEndoplasmic Reticulum-Associated DegradationEndoplasmic Reticulum StressIntracellular Signaling Peptides and ProteinsMiceMice, Mutant StrainsMitochondriaMitochondrial MembranesReceptors, sigmaSigma-1 ReceptorThermogenesisUbiquitin-Protein LigasesIntracellular Signaling Peptides and ProteinsReceptors, sigmaSel1h protein, mouseSigma-1 ReceptorSyvn1 protein, mouseUbiquitin-Protein Ligases
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