Evidence map›Paper›PMID 32193338›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Centromere scission drives chromosome shuffling and reproductive isolation.

Vikas Yadav, Sheng Sun, Marco A Coelho, Joseph Heitman

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
10.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 81 citations in OpenAlex.

  1. Progresses of transposon research inSynthetic and systems biotechnology · 2026
    Review
  2. Article
  3. Article
  4. Dissecting the homeodomainbioRxiv : the preprint server for biology · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Tracing the evolution and genomic dynamics of mating-type loci inbioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Review
  13. Convergent Patterns of Karyotype Evolution Underlying Karyotype Uniformity in Conifers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  14. Discovery of CONature microbiology · 2024
    Article
  15. Article
  16. Article
  17. Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Vikas YadavDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0003-2650-9035
Sheng SunDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-2895-1153
Marco A CoelhoDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710.ORCID 0000-0002-5716-0561
Joseph HeitmanDepartment of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710 heitm001@duke.edu.
Duke Medical Center · US

Funding

Structure, function, and evolution of the Cryptococcus MAT locusR01AI050113 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2002 to 2024
$8.5M
ROLE OF CALCINEURIN IN C. NEOFORMANS MATING AND FRUITINGR01AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 1997 to 2025
$6.7M
Genetics of Cryptococcus sexual reproductionR37AI039115 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH · 2011 to 2020
$4.9M
Structural Biological Development of Fungal-Specific Calcineurin InhibitorsR01AI112595 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH, SCHUMACHER, MARIA · 2014 to 2017
$2.5M
Structural Biological Development of Fungal-Specific Calcineurin InhibitorsR56AI112595 · NIAID · DUKE UNIVERSITY · PI HEITMAN, JOSEPH, HONG, JIYONG · 2020 to 2020
$669k
NIAID NIH HHS R01 AI039115NIAID NIH HHS R01 AI050113NIAID NIH HHS R01 AI112595NIAID NIH HHS R37 AI039115NIAID NIH HHS R56 AI112595
6 · The paper itself

Abstract

A fundamental characteristic of eukaryotic organisms is the generation of genetic variation via sexual reproduction. Conversely, significant large-scale genome structure variations could hamper sexual reproduction, causing reproductive isolation and promoting speciation. The underlying processes behind large-scale genome rearrangements are not well understood and include chromosome translocations involving centromeres. Recent genomic studies in the

Indexed as

Reproductive IsolationCentromereChromosomal InstabilityChromosomesCRISPR-Cas SystemsCryptococcosisCryptococcus neoformansDNA Breaks, Double-StrandedGenome, FungalGenomicsHumansTranslocation, Geneticchromosome translocationCryptococcus neoformansDSB repairkaryotype evolutionretrotransposons

Identifiers

PMID32193338
PMCPMC7149388
OpenAlexW3011460730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.