ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
Cortical Tonotopic Map Changes in Humans Are Larger in Hearing Loss Than in Additional Tinnitus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 67 citations in OpenAlex.
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Neuronal mechanisms underlying binaural performance with cochlear implant in single-sided deafness: a [European journal of nuclear medicine and molecular imaging · 2026Article
- Application of neurodegenerative disease treatment strategies in tinnitus: mechanisms, translation, and prospects.Frontiers in aging neuroscience · 2026Review
- Hearing Aid Amplification Schemes Adjusted to Tinnitus Pitch: A Randomized Controlled Trial.Audiology research · 2025Article
- The Influence of Carotid and Vertebral Doppler Ultrasonography and Brain MRI Abnormalities on Hearing Levels, Tinnitus Intensities and Frequencies.Audiology research · 2025Article
- Editorial: Bridging the gap between the different pillars of tinnitus research.Frontiers in neuroscience · 2025Article
- Correlation Between the Pitch and Loudness of Tinnitus, Hearing Levels, and Tinnitus Handicap Inventory Scores in Patients with Chronic Subjective Tinnitus.Journal of clinical medicine · 2024Article
- Tinnitus is associated with increased extracellular matrix density in the auditory cortex of Mongolian gerbils.BMC neuroscience · 2024Article
- Sound-Evoked Neural Activity in Normal-Hearing Tinnitus: Effects of Frequency and Stimulated Ear Side.Brain sciences · 2024Article
- Attention-Modulated Cortical Responses as a Biomarker for Tinnitus.Brain sciences · 2024Article
- Does age protect against loss of tonotopy after acute deafness in adulthood?Frontiers in cellular neuroscience · 2024Article
- Map plasticity following noise exposure in auditory cortex of rats: implications for disentangling neural correlates of tinnitus and hyperacusis.Frontiers in neuroscience · 2024Article
- Eavesdropping on Tinnitus Using MEG: Lessons Learned and Future Perspectives.Journal of the Association for Research in Otolaryngology : JARO · 2023Review
- Targeting the Limbic System: Insights into Its Involvement in Tinnitus.International journal of molecular sciences · 2023Review
- Tinnitus and Multimodal Cortical Interaction.Laryngo- rhino- otologie · 2023Article
- Editorial: Auditory perception and phantom perception in brains, minds and machines.Frontiers in neuroscience · 2023Article
- Dual-site transcranial direct current stimulation to treat tinnitus: a randomized controlled trial.Brain : a journal of neurology · 2022Article
- Tinnitus Perception in Light of a Parietal Operculo-Insular Involvement: A Review.Brain sciences · 2022Review
- Functional changes in the auditory cortex and associated regions caused by different acoustic stimuli in patients with presbycusis and tinnitus.Frontiers in neuroscience · 2022Article
- Tinnitus: at a crossroad between phantom perception and sleep.Brain communications · 2022Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neural plasticity due to hearing loss results in tonotopic map changes. Several studies have suggested a relation between hearing loss-induced tonotopic reorganization and tinnitus. This large fMRI study on humans was intended to clarify the relations between hearing loss, tinnitus, and tonotopic reorganization. To determine the differential effect of hearing loss and tinnitus, both male and female participants with bilateral high-frequency hearing loss, with and without tinnitus, and a control group were included. In a total of 90 participants, bilateral cortical responses to sound stimulation were measured with loudness-matched pure-tone stimuli (0.25-8 kHz). In the bilateral auditory cortices, the high-frequency sound-evoked activation level was higher in both hearing-impaired participant groups, compared with the control group. This was most prominent in the hearing loss group without tinnitus. Similarly, the tonotopic maps for the hearing loss without tinnitus group were significantly different from the controls, whereas the maps of those with tinnitus were not. These results show that higher response amplitudes and map reorganization are a characteristic of hearing loss, not of tinnitus. Both tonotopic maps and response amplitudes of tinnitus participants appear intermediate to the controls and hearing loss without tinnitus group. This observation suggests a connection between tinnitus and an incomplete form of central compensation to hearing loss, rather than excessive adaptation. One implication of this may be that treatments for tinnitus shift their focus toward enhancing the cortical plasticity, instead of reversing it.
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