ArticleNeuroImage. Clinical2020
Connectome-wide search for functional connectivity locus associated with pathological rumination as a target for real-time fMRI neurofeedback intervention.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Whole-brain mechanism of neurofeedback therapy: predictive modeling of neurofeedback outcomes on repetitive negative thinking in depression.Translational psychiatry · 2024Trial
- Real-Time fMRI Functional Connectivity Neurofeedback Reducing Repetitive Negative Thinking in Depression: A Double-Blind, Randomized, Sham-Controlled Proof-of-Concept Trial.Psychotherapy and psychosomatics · 2023Trial
- Neurofeedback in Major Depression.Advances in experimental medicine and biology · 2026Review
- Functional brain network dynamics of brooding in depression: Insights from real-time fMRI neurofeedback.Journal of affective disorders · 2025Article
- Clinical response to neurofeedback in major depression relates to subtypes of whole-brain activation patterns during training.Molecular psychiatry · 2025Article
- Aberrant cerebral activity in patients with unruptured intracranial aneurysm: a resting-state functional MRI study.Brain structure & function · 2025Article
- Article
- Functional brain network dynamics of brooding in depression: insights from real-time fMRI neurofeedback.medRxiv : the preprint server for health sciences · 2024Article
- A three-dimensional model of neural activity and phenomenal-behavioral patterns.Molecular psychiatry · 2024Review
- Thalamo-cortical circuits associated with trait- and state-repetitive negative thinking in major depressive disorder.Journal of psychiatric research · 2023Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.Journal of affective disorders · 2023Article
- Trait repetitive negative thinking in depression is associated with functional connectivity in negative thinking state rather than resting state.bioRxiv : the preprint server for biology · 2023Article
- Predicting the future of neuroimaging predictive models in mental health.Molecular psychiatry · 2022Review
- Depressive symptoms reduce when dorsolateral prefrontal cortex-precuneus connectivity normalizes after functional connectivity neurofeedback.Scientific reports · 2022Article
- A Library for fMRI Real-Time Processing Systems in Python (RTPSpy) With Comprehensive Online Noise Reduction, Fast and Accurate Anatomical Image Processing, and Online Processing Simulation.Frontiers in neuroscience · 2022Article
- Disrupted Spatiotemporal Complexity of Resting-State Electroencephalogram Dynamics Is Associated With Adaptive and Maladaptive Rumination in Major Depressive Disorder.Frontiers in neuroscience · 2022Article
- Editorial: Clinical Neurofeedback.NeuroImage. Clinical · 2022Article
- Cognitive effects of rapid-acting treatments for resistant depression: Just adverse, or contributing to clinical efficacy?Journal of psychiatric research · 2021Review
- Long-term stability of computational parameters during approach-avoidance conflict in a transdiagnostic psychiatric patient sample.Scientific reports · 2021Article
- Mindful Positive Emotion Regulation as a Treatment for Addiction: From Hedonic Pleasure to Self-Transcendent Meaning.Current opinion in behavioral sciences · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Real-time fMRI neurofeedback (rtfMRI-nf) enables noninvasive targeted intervention in brain activation with high spatial specificity. To achieve this promise of rtfMRI-nf, we introduced and demonstrated a data-driven framework to design a rtfMRI-nf intervention through the discovery of precise target location associated with clinical symptoms and neurofeedback signal optimization. Specifically, we identified the functional connectivity locus associated with rumination symptoms, utilizing a connectome-wide search in resting-state fMRI data from a large cohort of mood and anxiety disorder individuals (N = 223) and healthy controls (N = 45). Then, we performed a rtfMRI simulation analysis to optimize the online functional connectivity neurofeedback signal for the identified functional connectivity. The connectome-wide search was performed in the medial prefrontal cortex and the posterior cingulate cortex/precuneus brain regions to identify the precise location of the functional connectivity associated with rumination severity as measured by the ruminative response style (RRS) scale. The analysis found that the functional connectivity between the loci in the precuneus (-6, -54, 48 mm in MNI) and the right temporo-parietal junction (RTPJ; 49, -49, 23 mm) was positively correlated with RRS scores (depressive, p < 0.001; brooding, p < 0.001; reflective, p = 0.002) in the mood and anxiety disorder group. We then performed a rtfMRI processing simulation to optimize the online computation of the precuneus-RTPJ connectivity. We determined that the two-point method without a control region was appropriate as a functional connectivity neurofeedback signal with less dependence on signal history and its accommodation of head motion. The present study offers a discovery framework for the precise location of functional connectivity targets for rtfMRI-nf intervention, which could help directly translate neuroimaging findings into clinical rtfMRI-nf interventions.
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