Evidence map›Paper›PMID 32192826›Full record

ArticleJournal of dermatological science2020

SJS/TEN 2019: From science to translation.

Wan-Chun Chang, Riichiro Abe, Paul Anderson, Wanpen Anderson, Michael R Ardern-Jones, Thomas M Beachkofsky, Teresa Bellón, Agnieszka K Biala, Charles Bouchard, Gianpiero L Cavalleri and 60 more

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Journal of dermatological science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 33 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 2 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 74 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The immunogenicity and safety of adenoviral-based vaccines.Current opinion in allergy and clinical immunology · 2026
    Review
  4. Article
  5. Article
  6. Toxic Epidermal Necrolysis Induced by First-Line Helicobacter pylori Eradication Therapy: A Case Report.The Korean journal of helicobacter and upper gastrointestinal research · 2025
    Article
  7. Article
  8. Challenges in Diagnosing and Treatment of Pediatric Necrotic Skin Conditions: A Retrospective Study.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Cost-effectiveness ofPharmacogenomics · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

70 authors at 20 institutions in 15 countries.

Wan-Chun ChangDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Riichiro AbeNiigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Paul AndersonStevens-Johnson Syndrome Foundation, Westminster, CO, USA.
Wanpen AndersonStevens-Johnson Syndrome Foundation, Westminster, CO, USA.
Michael R Ardern-JonesFaculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK.
Thomas M BeachkofskyWilford Hall Ambulatory Surgical Center, Lackland Air Force Base, TX, USA.
Teresa BellónDrug Hypersensitivity Group, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.
Agnieszka K BialaDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Charles BouchardLoyola University Medical Center, Chicago, IL, USA.
Gianpiero L CavalleriSchool of Pharmacy and Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; FutureNeuro SFI Research Centre, Royal College of Surgeons in Ireland, Dublin, Ireland.
Nicole ChapmanSJS Awareness Oregon, Klamath Falls, OR, USA.
James ChodoshMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Hyon K ChoiDivision of Rheumatology, Allergy and Immunology, Massachusetts General Hospital, Boston, MA, USA.
Ricardo R CibottiNational Institute of Arthritis and Musculoskeletal and Skin Diseases, NIH, Bethesda, MD, USA.
Sherrie J DivitoDepartment of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Karen DewarGenome Canada, Ottawa, ON, Canada.
Ulrike DehaeckDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, BC, Canada.
Mahyar EtminanDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver, BC, Canada.
Diane ForbesCanadian Institutes of Health Research, Ottawa, ON, Canada.
Esther FuchsDepartment of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA.
Jennifer L GoldmanChildren's Mercy Hospital Kansas City, Kansas City, MO, USA.
James H HolmesWake Forest University School of Medicine, WFBMC Burn Center, Winston-Salem, NC, USA.
Elyse A HopeGenome British Columbia, Vancouver, BC, Canada.
Shuen-Iu HungCancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; Institute of Pharmacology, National Yang-Ming University, Taipei, Taiwan.
Chia-Ling HsiehEden Social Welfare Foundation, Taipei, Taiwan.
Alfonso IovienoDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital Eye Care Center, Vancouver, BC, Canada.
Julienne JagdeoGenome British Columbia, Vancouver, BC, Canada.
Mee Kum KimDepartment of Ophthalmology, Seoul National University College of Medicine, Seoul, South Korea.
David M KoelleDepartment of Medicine, University of Washington, Seattle, WA, USA.
Mario E LacoutureMemorial Sloan Kettering Cancer Center, New York, NY, USA.
Sophie Le PallecAssociation des malades des syndromes de Lyell et de Stevens-Johnson (Amalyste), Paris, France.
Rannakoe J LehloenyaDivision of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Robyn LimHealth Products and Food Branch, Health Canada, Ottawa, ON, Canada.
Angie LoweSJS/TEN International Awareness (STIA), Lucky Lake, SK, Canada.
Jean McCawleyStevens-Johnson Syndrome Foundation, Westminster, CO, USA.
Julie McCawleyStevens-Johnson Syndrome Foundation, Westminster, CO, USA.
Robert G MichelettiDepartment of Dermatology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Maja MockenhauptDokumentationszentrum schwerer Hautreaktionen (dZh), Department of Dermatology, Medical Center and Medical Faculty, University of Freiburg, Freiburg, Germany.
Katie NiemeyerSJ Syndrome of Texas, Austin, TX, USA.
Michael A NorcrossLaboratory of Immunology, Division of Biotechnology Review and Research III (DBRR III), Office of Biotechnology Products (OBP), Office of Pharmaceutical Quality (OPQ), Center for Drug Evaluation and Research (CDER), FDA, Silver Spring, MD, USA.
Douglas ObohStevens-Johnson Syndrome Foundation, Westminster, CO, USA.
Cristina OlteanuDivision of Dermatology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Helena B PasiekaDepartment of Dermatology, MedStar Washington Hospital Center, Washington, DC, USA.
Jonathan PeterDivision of Allergy and Clinical Immunology, Department of Medicine, University of Cape Town, Cape Town, South Africa.
Munir PirmohamedDepartment of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK.
Michael RiederDepartment of Paediatrics, Children's Hospital/London Health Sciences Centre, Schulich School of Medicine & Dentistry, Western University, London, ON, Canada.
Hajirah N SaeedMassachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA.
Neil H ShearSunnybrook Health Sciences Centre, University of Toronto, ON, Canada.
Christine ShiehDepartment of Ophthalmology, Vanderbilt Eye Institute, Nashville, TN, USA.
Sabine StrausDutch Medicines Evaluation Board, Pharmacovigilance Risk Assessment Committee, European Medicines Agency, Utrecht, the Netherlands.
Chonlaphat SukasemRamathibodi Hospital, Mahidol University, Bangkok, Thailand.
Cynthia SungHealth Products Regulation Group, Health Sciences Authority Singapore, Duke-NUS Medical School, Singapore.
Jason A TrubianoDepartment of Infectious Diseases, Austin Health, Heidelberg, Germany; Department of Medicine, University of Melbourne, Victoria, Australia.
Sheng-Ying TsouEden Social Welfare Foundation, Taipei, Taiwan.
Mayumi UetaDepartment of Frontier Medical Science and Technology for Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
Simona VolpiNational Human Genome Research Institute, NIH, Bethesda, MD, USA.
Chen WanGenome British Columbia, Vancouver, BC, Canada.
Hongsheng WangInstitute of Dermatology, Chinese Academy of Medical Sciences, National Center for STD and Leprosy Control, China CDC, Nanjing, China.
Zhao-Qing WangEden Social Welfare Foundation, Taipei, Taiwan.
Jessica WeintraubDivision of Pharmacovigilance I, Office of Surveillance and Epidemiology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, USA.
Cindy WhaleSJS Canada, Brantford, ON, Canada.
Lisa M WheatleyNational Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, USA.
Sonia Whyte-CroasdaileSJS Canada, Brantford, ON, Canada.
Kristina B WilliamsDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Galen WrightDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada.
Sonia N YeungDepartment of Ophthalmology and Visual Sciences, University of British Columbia, Vancouver General Hospital Eye Care Center, Vancouver, BC, Canada.
Li ZhouDivision of General Internal Medicine and Primary Care, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Wen-Hung ChungDepartment of Dermatology, Drug Hypersensitivity Clinical and Research Center, Chang Gung Memorial Hospital, Linkou, Taipei, Keelung, Taoyuan, Taiwan; Cancer Vaccine and Immune Cell Therapy Core Laboratory, Chang Gung Immunology Consortium, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Dermatology, Xiamen Chang Gung Hospital, Xiamen, China; Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung, Taiwan. Electronic address: chung1@cgmh.org.tw.
Elizabeth J PhillipsDepartment of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Australia; Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: elizabeth.j.phillips@vumc.org.
Bruce C CarletonDivision of Translational Therapeutics, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada; British Columbia Children's Hospital Research Institute, Vancouver, BC, Canada. Electronic address: bcarleton@popi.ubc.ca.
Rome Foundation · USUniversity of British Columbia · CAGenome British Columbia · CACenter for Drug Evaluation and Research · USHarvard University · USUniversity of Cape Town · ZAUniversity of Washington · USVancouver General Hospital · CAVanderbilt University Medical Center · USBC Children's Hospital · CABrigham and Women's Hospital · USCanadian Institutes of Health Research · CAChildren's Mercy Hospital · USChinese Academy of Medical Sciences Dermatology Hospital · CNGenome Canada · CAHealth Canada · CAHealth Sciences Authority · SGHealth Sciences Centre · CAHospital La Paz Institute for Health Research · ESKyoto Prefectural University of Medicine · JP

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Investigating a novel cell population in delayed-onset drug hypersensitivity reactionsDP5OD023091 · OD · BRIGHAM AND WOMEN'S HOSPITAL · PI DIVITO, SHERRIE JILL · 2016 to 2020
$2.1M
IMmune-mediated Adverse drug Reactions In African HIV endemic setting (IMARI-SA study)K43TW011178 · FIC · UNIVERSITY OF CAPE TOWN LUNG INSTITUTE · PI PETER, JONATHAN · 2018 to 2022
$648k
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis 2019: From Science to TranslationR13AR074889 · NIAMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2019 to 2019
$39k
FIC NIH HHS K43 TW011178Medical Research Council MR/L006758/1NCI NIH HHS P30 CA008748NIAMS NIH HHS R13 AR074889NIH HHS DP5 OD023091
6 · The paper itself

Abstract

Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN) are potentially life-threatening, immune-mediated adverse reactions characterized by widespread erythema, epidermal necrosis, and detachment of skin and mucosa. Efforts to grow and develop functional international collaborations and a multidisciplinary interactive network focusing on SJS/TEN as an uncommon but high burden disease will be necessary to improve efforts in prevention, early diagnosis and improved acute and long-term management. SJS/TEN 2019: From Science to Translation was a 1.5-day scientific program held April 26-27, 2019, in Vancouver, Canada. The meeting successfully engaged clinicians, researchers, and patients and conducted many productive discussions on research and patient care needs.

Indexed as

Congresses as TopicGlobal Burden of DiseaseGlobal HealthHealth Services Needs and DemandHumansInternational CooperationPatient Care TeamPharmacogeneticsRegistriesStevens-Johnson SyndromeTranslational Research, BiomedicalHuman leukocyte antigen (HLA)PharmacogenomicsPharmacovigilanceSevere cutaneous adverse reaction (SCAR)Stevens-Johnson syndrome (SJS)Toxic epidermal necrolysis (TEN)

Identifiers

PMID32192826
PMCPMC7261636
OpenAlexW3009348865

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.