Evidence map›Paper›PMID 32192514›Full record

ArticleMalaria journal2020

Practical example of multiple antibody screening for evaluation of malaria control strategies.

Marie-Louise Varela, David Koffi, Michael White, Makhtar Niang, Babacar Mbengue, Fatoumata Diene Sarr, André Offianan Touré, Ronald Perraut

Open access · goldAbstract read
In one paragraph

Article in Malaria journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. eLife · 2021
    Pooled it
  2. Article
  3. Article
  4. Parasite epidemiology and control · 2024
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Marie-Louise VarelaUnité d'Immunologie, Institut Pasteur de Dakar, Dakar, Senegal.
David KoffiUnité de Paludologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Michael WhiteMalaria Unit, Parasites and hosts, Institut Pasteur, Paris, France.
Makhtar NiangUnité d'Immunologie, Institut Pasteur de Dakar, Dakar, Senegal.
Babacar MbengueUnité d'Immunogénétique, Institut Pasteur de Dakar, Dakar, Senegal.
Fatoumata Diene SarrUnité d'Epidémiologie, Institut Pasteur de Dakar, Dakar, Senegal.
André Offianan TouréUnité de Paludologie, Institut Pasteur de Côte d'Ivoire, Abidjan, Côte d'Ivoire.
Ronald PerrautUnité d'Immunologie, Institut Pasteur de Dakar, Dakar, Senegal. perraut@pasteur.sn.
Institut Pasteur de Dakar · SNInstitut Pasteur de Côte d'Ivoire · CIInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOngoing efforts to fight Plasmodium falciparum malaria has reduced malaria in many areas, but new tools are needed to monitor further progress, including indicators of decreasing exposure to parasite infection. Sero-surveillance is considered promising to monitor exposure, transmission and immunity.

methodsIgG responses to three antigen biomarkers were evaluated in a retrospective study involving: (i) surveys of 798 asymptomatic villagers from 2 Senegalese endemic settings conducted before 2002 and after the 2013 intensification of control measures, and (ii) in 105 symptomatic individuals from different settings in Côte d'Ivoire. Response to up to eight P. falciparum antigens, including recombinant MSP1p9 antigen and LSA1

resultsMSP1p9 and LSA1

conclusionFor standard screening of population immune status at sites envisaging elimination, the use of ELISA-based assays targeting selected antigens can contribute to provide important epidemiologic surveillance data to aid malaria control programmes.

Indexed as

AdolescentAdultAgedAntibodies, ProtozoanAntigens, ProtozoanAsymptomatic InfectionsBiomarkersChildChild, PreschoolCote d'IvoireEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GInfantLongitudinal StudiesMalaria, FalciparumAntibodies, ProtozoanAntigens, ProtozoanBiomarkersImmunoglobulin GAsymptomatic carriageBiomarkersELISAIgGIvory CoastMAGPIXMalariaMultiple antigensMultiplexPlasmodium falciparumSymptomatic malaria

Identifiers

PMID32192514
PMCPMC7082935
OpenAlexW3012902323

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.