ReviewBMC infectious diseases2020
Inflammatory pseudotumor associated with HSV infection of rectal vascular endothelium in a patient with HIV: a case report and literature review.
Review in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Inflammatory Pseudotumour in Common Seal (Phoca vitulina): A Case Report.Veterinary medicine and science · 2026Article
- Malignancy Masquerade: Inclusion-Negative Herpes Simplex Virus Rectal Pseudotumor in a Patient With HIV.ACG case reports journal · 2025Article
- Herpes Simplex Virus Pseudotumor Masking as Gastric Malignancy.ACG case reports journal · 2023Article
- Herpes Proctitis in Men Mimicking Rectal Adenocarcinoma: Two Cases of an Easily Overlooked Diagnosis in the Proximal Rectum.Case reports in pathology · 2023Article
- HIV-related bilateral inflammatory myofibroblastic tumors of the adrenal gland: a case report and literature review.AIDS research and therapy · 2022Review
- Inflammatory Pseudotumor of Liver and Budd-Chiari Syndrome: a Tale During 10 Years of Follow-up in a Child with Severe Congenital Neutropenia.Journal of clinical immunology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHerpes simplex virus (HSV) typically infects oral or anogenital squamous epithelium and causes blisters and ulcerations. Here we reported an unusual case of HSV induced exuberant rectal inflammatory pseudotumor with vascular endothelial involvement. CASE PRESENTATIONS: A 52-year old man with HIV presented with abdominal pain, rectal drainage and constipation. Proctoscopy and CT scans revealed an 8 × 5 × 4 cm circumferential, mid-lower rectal mass that was concerning for malignancy. PET-CT showed mild to moderate FDG uptake of the rectal mass. Repeated biopsies showed exuberant lymphoplasmacytic inflammation with rich eosinophils and necrosis in the submucosa and scattered single or multi-nucleated viral inclusions in vascular endothelial cells that were positive for HSV by immunostains. There was no evidence of malignancy on histology or by immunostains. The patient started valacyclovir for three weeks and symptoms resolved after the antiviral therapy. Follow-up CT and sigmoidoscopy with biopsy revealed no rectal mass or drainable collection.
conclusionsHSV may present as proctitis with exuberant inflammatory response and mass-like lesion, and damages vascular endothelial cells in patients with HIV. The HSV-associated mass-like lesion can be effectively treated by 3-week valacyclovir.
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Registered trials
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