Evidence map›Paper›PMID 32192190›Full record

ArticleCells2020

Insulin Resistance Promotes Parkinson's Disease through Aberrant Expression of α-Synuclein, Mitochondrial Dysfunction, and Deregulation of the Polo-Like Kinase 2 Signaling.

Chien-Tai Hong, Kai-Yun Chen, Weu Wang, Jing-Yuan Chiu, Dean Wu, Tsu-Yi Chao, Chaur-Jong Hu, Kai-Yin David Chau, Oluwaseun Adebayo Bamodu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 4 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 4 syntheses or guidelines pooled it, 123 citations in OpenAlex.

  1. Efficacy and safety of GLP-1 receptor agonists in Parkinson's disease: a systematic review and meta-analysis of randomized clinical trials.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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  16. Polo-like kinase2 regulates renal tubulointerstitial fibrosis via notch signaling pathway in diabetic kidney disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Chien-Tai HongDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.
Kai-Yun ChenCollege of Medical Science and Technology, Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Weu WangDepartment of Surgery, Taipei Medical University Hospital, Taipei City 110, Taiwan.ORCID 0000-0002-0903-0535
Jing-Yuan ChiuCollege of Medical Science and Technology, Graduate Institute of Neural Regenerative Medicine, Taipei Medical University, Taipei City 110, Taiwan.
Dean WuDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.ORCID 0000-0003-0147-1640
Tsu-Yi ChaoTaipei Cancer Center, Taipei Medical University, Taipei City 110, Taiwan.
Chaur-Jong HuDepartment of Neurology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.
Kai-Yin David ChauDepartment of Clinical and Movement Neuroscience, Institute of Neurology, University College London, London WC1N 3BG, UK.
Oluwaseun Adebayo BamoduDepartment of Hematology & Oncology, Taipei Medical University-Shuang Ho Hospital, New Taipei City 235, Taiwan.ORCID 0000-0001-8229-0408
Taipei Medical University-Shuang Ho Hospital · TWTaipei Medical University · TWTaipei Medical University Hospital · TWUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Insulin ResistanceSignal Transductionalpha-SynucleinAnimalsDiabetes Mellitus, Type 2Disease ProgressionDopaminergic NeuronsGenome, HumanHumansMaleMice, Inbred C57BLMitochondriaModels, BiologicalParkinson DiseasePeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphoserinealpha-SynucleinPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPhosphoserinePLK2 protein, humanPPARGC1A protein, humanProtein Serine-Threonine KinasesReactive Oxygen SpeciesTyrosine 3-Monooxygenasediabetesinsulin resistancemitochondriaParkinson’s diseasePLK2polo-like kinase 2SNCAα-synuclein

Identifiers

PMID32192190
PMCPMC7140619
OpenAlexW3011296966

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.