Trial reportNutrients2020
Human Milk Oligosaccharide Profile Variation Throughout Postpartum in Healthy Women in a Brazilian Cohort.
Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 68 citations in OpenAlex.
- Associations between maternal obesity and offspring gut microbiome in the first year of life.Pediatric obesity · 2022Trial
- Decoding the HMO‒microbiome axis: bridging maternal milk to infant health outcomes.Gut microbes · 2026Review
- Varied human milk oligosaccharides in human milk from mothers treated with antidepressants and anti-inflammatories.Pediatric research · 2026Article
- Quantitative Profiling of Human Milk Oligosaccharides Across Asian Countries Reveals Secretor-Dependent Variations and Implications for Infant Nutrition.International journal of molecular sciences · 2026Article
- Longitudinal changes of human milk oligosaccharides in Japan and their associations with maternal or infant characteristics.Frontiers in nutrition · 2026Article
- Molecular detection ofNew microbes and new infections · 2025Article
- Sensitive Profiling of Human Milk Oligosaccharides in Human Colostrum and Breast Milk by Capillary Electrophoresis-Mass Spectrometry.Journal of separation science · 2025Article
- Article
- A Pilot Study Exploring the Relationship Between Milk Composition and Microbial Capacity in Breastfed Infants.Nutrients · 2025Article
- Changes in and relationships between human milk oligosaccharides and microRNAs in milk-derived extracellular vesicles during the first 4 months of lactation.Frontiers in nutrition · 2025Article
- Absolute quantification of eight human milk oligosaccharides in breast milk to evaluate their concentration profiles and associations with infants' neurodevelopmental outcomes.Journal of food science · 2024Article
- The Association Between Maternal Psychological Health and Human Milk Oligosaccharide Composition.Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine · 2024Article
- Modifiable and Non-Modifiable Factors That Affect Human Milk Oligosaccharides Composition.Nutrients · 2024Review
- Association between the third trimester maternal serum metabolome and child growth and development through the first year of life.Scientific reports · 2024Article
- Exploring the impact of maternal factors and dietary habits on human milk oligosaccharide composition in early breastfeeding among Mexican women.Scientific reports · 2024Article
- Article
- Patterns of Human Milk Oligosaccharides in Mature Milk Are Associated with Certain Gut Microbiota in Infants.Nutrients · 2024Article
- Linking human milk oligosaccharide metabolism and early life gut microbiota: bifidobacteria and beyond.Microbiology and molecular biology reviews : MMBR · 2024Review
- Consistency and Variability of the Human Milk Oligosaccharide Profile in Repeat Pregnancies.Nutrients · 2024Article
- Label-Free Liquid Chromatography-Mass Spectrometry Quantitation of RelativeInternational journal of molecular sciences · 2024Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Human milk oligosaccharide (HMO) composition varies throughout lactation and can be influenced by maternal characteristics. This study describes HMO variation up to three months postpartum and explores the influences of maternal sociodemographic and anthropometric characteristics in a Brazilian prospective cohort. We followed 101 subjects from 28-35 gestational weeks (baseline) and throughout lactation at 2-8 (visit 1), 28-50 (visit 2) and 88-119 days postpartum (visit 3). Milk samples were collected at visits 1, 2 and 3, and 19 HMOs were quantified usinghigh-performance liquid chromatography with fluorescence detection (HPLC-FL). Friedman post-hoc test, Spearman rank correlation for maternal characteristics and HMOs and non-negative matrix factorization (NMF) were used to define the HMO profile. Most women were secretors (89.1%) and presented high proportion of 2'-fucosyllactose (2ꞌFL) at all three sample times, while lacto-N-tetraose (LNT, 2-8 days) and lacto-N-fucopentaose II (LNFPII, 28-50 and 88-119 days) were the most abundant HMOs in non-secretor women. Over the course of lactation, total HMO weight concentrations (g/L) decreased, but total HMO molar concentrations (mmol/L) increased, highlighting differential changes in HMO composition over time. In addition, maternal pre-pregnancy body mass index (BMI) and parity influence the HMO composition in healthy women in this Brazilian cohort.
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