ArticleJournal of clinical medicine2020
Bedside 3D Visualization of Lymphatic Vessels with a Handheld Multispectral Optoacoustic Tomography Device.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Optoacoustic muscle imaging.Journal of neuromuscular diseases · 2026Review
- Clinical translation of photoacoustic imaging using exogenous molecular contrast agents [Invited].Biomedical optics express · 2025Review
- Dual-wavelength photoacoustic imaging of sentinel lymph nodes in patients with melanoma and breast cancer.Photoacoustics · 2025Article
- Comparison of the Quality of Lymphatic Vessel Images Obtained Using Two Photoacoustic Imaging Systems.Plastic and reconstructive surgery. Global open · 2024Article
- Application of multispectral optoacoustic tomography for lower limb musculoskeletal sports injuries in adults.Photoacoustics · 2024Article
- Near-infrared multispectral photoacoustic analysis of lipids and intraplaque hemorrhage in human carotid artery atherosclerosis.Photoacoustics · 2024Article
- Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine.Journal of biomedical optics · 2023Review
- Imaging Modalities for Evaluating Lymphedema.Medicina (Kaunas, Lithuania) · 2023Review
- LED-based photoacoustic imaging for preoperative visualization of lymphatic vessels in patients with secondary limb lymphedema.Photoacoustics · 2023Article
- Desialylated Platelet Clearance in the Liver is a Novel Mechanism of Systemic Immunosuppression.Research (Washington, D.C.) · 2023Article
- Evolution of Anatomical Studies on the Arterial, Venous, and Lymphatic System in Plastic Surgery.Archives of plastic surgery · 2022Article
- Application of Photoacoustic Imaging for Lymphedema Treatment.Journal of reconstructive microsurgery · 2022Article
- Imaging of peripheral vascular malformations - current concepts and future perspectives.Molecular and cellular pediatrics · 2021Review
- Multichromatic near-infrared imaging to assess interstitial lymphatic and venous uptake in vivo.Journal of biomedical optics · 2021Article
- Biology of Lymphedema.Biology · 2021Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Identification of lymphatics by Indocyanine Green (ICG) lymphography in patients with severe lymphedema is limited due to the overlying dermal backflow. Nor can the method detect deep and/or small vessels. Multispectral optoacoustic tomography (MSOT), a real-time three- dimensional (3D) imaging modality which allows exact spatial identification of absorbers in tissue such as blood and injected dyes can overcome these hurdles. However, MSOT with a handheld probe has not been performed yet in lymphedema patients. We conducted a pilot study in 11 patients with primary and secondary lymphedema to test whether lymphatic vessels could be detected with a handheld MSOT device. In eight patients, we could not only identify lymphatics and veins but also visualize their position and contractility. Furthermore, deep lymphatic vessels not traceable by ICG lymphography and lymphatics covered by severe dermal backflow, could be clearly identified by MSOT. In three patients, two of which had advanced stage lymphedema, only veins but no lymphatic vessels could be identified. We found that MSOT can identify and image lymphatics and veins in real-time and beyond the limits of near-infrared technology during a single bedside examination. Given its easy use and high accuracy, the handheld MSOT device is a promising tool in lymphatic surgery.
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