ArticleIEEE transactions on bio-medical engineering2020
Evaluation of Durability of Transparent Graphene Electrodes Fabricated on Different Flexible Substrates for Chronic In Vivo Experiments.
Article in IEEE transactions on bio-medical engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 21 citations in OpenAlex.
- Toward therapnostic integration as a new paradigm for precision management of interstitial cystitis driven by medical-engineering convergence.Discover nano · 2026Review
- Controllable tip exposure of ultramicroelectrodes coated by diamond-like carbon via direct microplasma jet for enhanced stability and fidelity in single-cell recording.Microsystems & nanoengineering · 2025Article
- Atomically thin bioelectronics.Nature reviews. Materials · 2024Article
- High-density transparent graphene arrays for predicting cellular calcium activity at depth from surface potential recordings.Nature nanotechnology · 2024Article
- Multimodal monitoring of human cortical organoids implanted in mice reveal functional connection with visual cortex.Nature communications · 2022Article
- Review
- Polymer Skulls With Integrated Transparent Electrode Arrays for Cortex-Wide Opto-Electrophysiological Recordings.Advanced healthcare materials · 2022Article
- Fabrication of Planar Microelectrode Array Using Laser-Patterned ITO and SU-8.Micromachines · 2021Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo investigate chronic durability of transparent graphene electrodes fabricated on polyethylene terephthalate (PET) and SU-8 substrates for chronic in vivo studies.
methodsWe perform systematic accelerated aging tests to understand the chronic reliability and failure modes of transparent graphene microelectrode arrays built on PET and SU-8 substrates. We employ graphene microelectrodes fabricated on PET substrate in chronic in vivo experiments with transgenic mice.
resultsOur results show that graphene microelectrodes fabricated on PET substrate work reliably after 30 days accelerated aging test performed at 87 °C, equivalent to 960 days in vivo lifetime. We demonstrate stable chronic recordings of cortical potentials in multimodal imaging/recording experiments using transparent graphene microelectrodes fabricated on PET substrate. On the other hand, graphene microelectrode arrays built on SU-8 substrate exhibit extensive crack formation across microelectrode sites and wires after one to two weeks, resulting in total failure of recording capability for chronic studies.
conclusionPET shows superior reliability as a substrate for graphene microelectrode arrays for chronic in vivo experiments. SIGNIFICANCE: Graphene is a unique neural interface material enabling cross-talk free integration of electrical and optical recording and stimulation techniques in the same experiment. To date, graphene-based microelectrode arrays have been demonstrated in various multi-modal acute experiments involving electrophysiological sensing or stimulation, optical imaging and optogenetics stimulation. Understanding chronic reliability of graphene-based transparent interfaces is very important to expand the use of this technology for long-term behavioral studies with animal models.
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