ArticlePLoS pathogens2020
Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra.
Article in PLoS pathogens, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 48 citations in OpenAlex.
- Symbiont Reintroduction Alters Tumor Progression and Life-History Traits in the Tumor-Bearing Freshwater CnidarianEcology and evolution · 2026Article
- Stable association of a chlamydial symbiont with the freshwater predator hydra suggests broad host potential.The ISME journal · 2026Article
- Photodynamic Evaluation of Synthesized Chlorin-Desthiobiotin Conjugate with Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells In Vitro and in Hydra Organisms In Vivo.International journal of molecular sciences · 2025Article
- Article
- Ecology of vertical tumor transmission in the freshwater cnidarian Hydra oligactis.Scientific reports · 2025Article
- Environmental microbial reservoir influences the bacterial communities associated with Hydra oligactis.Scientific reports · 2024Article
- Discovery of deep-sea coral symbionts from a novel clade of marine bacteria with severely reduced genomes.Nature communications · 2024Article
- Cancer and One Health: tumor-bearing individuals can act as super spreaders of symbionts in communities.Scientific reports · 2024Article
- De novo evolution of transmissible tumours in hydra.Proceedings. Biological sciences · 2024Article
- Review
- Identifying disease-related microbes based on multi-scale variational graph autoencoder embedding Wasserstein distance.BMC biology · 2023Article
- The impact of food availability on tumorigenesis is evolutionarily conserved.Scientific reports · 2023Article
- Dysbiosis of intestinal homeostasis contribute to Whitmania pigra edema disease.Microbial biotechnology · 2023Article
- Spontaneously occurring tumors in different wild-derived strains of hydra.Scientific reports · 2023Article
- Environmental bacteria increase population growth of hydra at low temperature.Frontiers in microbiology · 2023Article
- Article
- Article
- Transmissible Cancer Evolution: The Under-Estimated Role of Environmental Factors in the "Perfect Storm" Theory.Pathogens (Basel, Switzerland) · 2022Article
- Mutation or not, what directly establishes a neoplastic state, namely cellular immortality and autonomy, still remains unknown and should be prioritized in our research.Journal of Cancer · 2022Review
- Dysbiosis of the Gut Microbiome Is Associated With Histopathology of Lung Cancer.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extent to which disturbances in the resident microbiota can compromise an animal's health is poorly understood. Hydra is one of the evolutionary oldest animals with naturally occurring tumors. Here, we found a causal relationship between an environmental spirochete (Turneriella spec.) and tumorigenesis in Hydra. Unexpectedly, virulence of this pathogen requires the presence of Pseudomonas spec., a member of Hydra´s beneficial microbiome indicating that dynamic interactions between a resident bacterium and a pathogen cause tumor formation. The observation points to the crucial role of commensal bacteria in maintaining tissue homeostasis and adds support to the view that microbial community interactions are essential for disease. These findings in an organism that shares deep evolutionary connections with all animals have implications for our understanding of cancer.
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