Trial reportJournal of applied physiology (Bethesda, Md. : 1985)2020
Countering disuse atrophy in older adults with low-volume leucine supplementation.
Trial report in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- The effect of protein or amino acid provision on immobilization-induced muscle atrophy in healthy adults: A systematic review and meta-analysis.Experimental physiology · 2024Pooled it
- The role of muscle disuse in muscular and cardiovascular fitness: A systematic review and meta-regression.European journal of sport science · 2024Pooled it
- Do dietary supplements prevent loss of muscle mass and strength during muscle disuse? A systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2023Pooled it
- The Aging Muscle in Experimental Bed Rest: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2021Pooled it
- Leucine supplementation does not attenuate the decline in daily muscle protein synthesis rates or preserve leg muscle mass during leg immobilization in young or older adults: a double-blind randomized trial.The American journal of clinical nutrition · 2026Trial
- Meals Containing Equivalent Total Protein from Foods Providing Complete, Complementary, or Incomplete Essential Amino Acid Profiles do not Differentially Affect 24-h Skeletal Muscle Protein Synthesis in Healthy, Middle-Aged Women.The Journal of nutrition · 2024Trial
- Review
- The effects of bed rest on cardiometabolic health: A systematic review and meta-analysis.Experimental physiology · 2026Article
- The transcriptomic signature of age and sex is not conserved in human primary myotubes.Skeletal muscle · 2026Article
- Associations of high protein supplements with gut microbiota and skeletal muscle mass in hospitalized older people.BMC geriatrics · 2025Article
- Integrated muscle protein synthesis during disuse and rehabilitation in late-midlife adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2025Article
- What Is 'Muscle Health'? A Narrative Review and Conceptual Framework.Journal of functional morphology and kinesiology · 2025Review
- Selected Nutrients to Oppose Muscle Disuse Following Arthroscopic Orthopedic Surgery: A Narrative Review.Nutrients · 2025Review
- DNA hypermethylation preceded by H3K27 trimethylation is linked to downregulation of gene expression in disuse muscle atrophy in male mice.Physiological reports · 2025Article
- Important Concepts in Protein Nutrition, Aging, and Skeletal Muscle: Honoring Dr Douglas Paddon-Jones (1969-2021) by Highlighting His Research Contributions.The Journal of nutrition · 2023Review
- Depressed Protein Synthesis and Anabolic Signaling Potentiate ACL Tear-Resultant Quadriceps Atrophy.The American journal of sports medicine · 2023Article
- The T allele of TCF7L2 rs7903146 is associated with decreased glucose tolerance after bed rest in healthy older adults.Scientific reports · 2022Article
- Improvements in sleep quality and fatigue are associated with improvements in functional recovery following hospitalization in older adults.Frontiers in sleep · 2022Article
- Early lean mass sparing effect of high-protein diet with excess leucine during long-term bed rest in women.Frontiers in nutrition · 2022Article
- Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Older adults are at increased risk of being bedridden and experiencing negative health outcomes including the loss of muscle tissue and functional capacity. We hypothesized that supplementing daily meals with a small quantity (3-4 g/meal) of leucine would partially preserve lean leg mass and function of older adults during bed rest. During a 7-day bed rest protocol, followed by 5 days of inpatient rehabilitation, healthy older men and women (67.8 ± 1.1 yr, 14 men; 6 women) were randomized to receive isoenergetic meals supplemented with leucine (LEU, 0.06 g/kg/meal;
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.