Evidence map›Paper›PMID 32191396›Full record

ArticleJournal of cellular and molecular medicine2020

Use of Tregs as a cell-based therapy via CD39 for benign prostate hyperplasia with inflammation.

Xi Jin, Tianhai Lin, Guang Yang, Huawei Cai, Bo Tang, Xinyang Liao, Huifang Li, Xiaoting Chen, Lina Gong, Hang Xu and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. CD38Frontiers in immunology · 2022
    Article
  7. Article
  8. CD39Frontiers in immunology · 2020
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 1 institution in 1 country.

Xi JinDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0003-3700-3339
Tianhai LinDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Guang YangAnimal Experimental Center, West China Hospital, Sichuan University, Chengdu, China.
Huawei CaiLaboratory of Clinical Nuclear Medicine, Department of Nuclear Medicine, West China Hospital, Sichuan University, Chengdu, China.
Bo TangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Xinyang LiaoDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Huifang LiResearch Core Facility, West China Hospital, Sichuan University, Chengdu, China.
Xiaoting ChenAnimal Experimental Center, West China Hospital, Sichuan University, Chengdu, China.
Lina GongDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Hang XuDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Yi SunDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Ping TanDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Jianqiong YinDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Hongwen MaDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Jianzhong AiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Kunjie WangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.ORCID 0000-0001-8289-2791
Qiang WeiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Lu YangDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Hong LiDepartment of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.
Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Benign prostatic hyperplasia (BPH) occurs most commonly among older men, often accompanied by chronic tissue inflammation. Although its aetiology remains unclear, autoimmune dysregulation may contribute to BPH. Regulatory T cells (Tregs) prevent autoimmune responses and maintain immune homeostasis. In this study, we aimed to investigate Tregs frequency, phenotype, and function in BPH patients and to evaluate adoptive transfer Tregs for immunotherapy in mice with BPH via CD39. Prostate specimens and peripheral blood from BPH patients were used to investigate Treg subsets, phenotype and Treg-associated cytokine production. Sorted CD39

Indexed as

Adoptive TransferAdultAnimalsApyraseAutoimmunityCytokinesDisease ProgressionGene Expression RegulationHumansImmunotherapyInflammationMaleMiceMice, Inbred BALB CPhenotypeProstateApyraseCytokinesENTPD1 protein, humanTestosterone Propionatebenign prostate hyperplasiaCD39immunotherapyregulatory T cellstransfusion

Identifiers

PMID32191396
PMCPMC7205803
OpenAlexW3010777283

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.