ReviewNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2020
An overview of frailty in kidney transplantation: measurement, management and future considerations.
Review in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
70 citing papers in PubMed, 3 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Understanding frailty across the kidney transplant continuum: a comprehensive systematic review of recent evidence.International urology and nephrology · 2026Pooled it
- Effects of intradialytic exercise on frailty in maintenance hemodialysis patients: a systematic review and meta-analysis.Frontiers in physiology · 2025Pooled it
- Prevalence of physical frailty and impact on survival in patients with chronic kidney disease: a systematic review and meta-analysis.BMC nephrology · 2023Pooled it
- Frailty assessment in kidney transplantation: insights from a European survey.Clinical kidney journal · 2026Article
- Impact of Comorbidities on the Long-Term Survival Rate of Patients Aged 60 Years and Older Undergoing Deceased Donor Kidney Transplantation Versus Continued Waitlisting.Journal of clinical medicine · 2026Article
- Comparison of Multiple Frailty Scoring Metrics in Renal Transplant Candidates: A Large Single-center Cohort Study.Transplantation direct · 2026Article
- Frailty Screening and Prehabilitation Before Kidney Transplant Listing: A Practical Narrative Review.Cureus · 2026Review
- Frailty Matters-But Contextualize the Clinical Decision.Kidney international reports · 2025Article
- Frailty Impact on Kidney Transplantation in Older People.Kidney international reports · 2025Article
- Immunosuppressant-Induced Alteration of Gut Microbiota Causes Loss of Skeletal Muscle Mass: Evidence from Animal Experiments Using Mice and Observational Study on Humans.Journal of clinical medicine · 2025Article
- Kidney replacement therapies in the older person: challenges to decide the best option.Clinical kidney journal · 2025Review
- Predictors of static and dynamic balance control in kidney transplant recipients.Wiener klinische Wochenschrift · 2025Article
- Infection Risk in Older Kidney Transplant Recipients: An Analysis in the Era of Expanded Age Limits.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Frailty Prevalence and Characterization Among Kidney Transplant Candidates in Spain: A Multicenter Study.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Exercise attitudes and practices among adults listed for kidney transplantation: a survey of a diverse patient cohort.Frontiers in sports and active living · 2025Article
- Prevalence and factors associated with frailty among incident kidney transplant patients: a cross-sectional study.Sao Paulo medical journal = Revista paulista de medicina · 2025Article
- Frailty and sarcopenia metabolomic signatures in kidney transplant candidates: the FRAILMar study.Clinical kidney journal · 2025Article
- Frailty in Kidney Disease: A Comprehensive Review to Advance Its Clinical and Research Applications.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2025Review
- Frailty and Prehabilitation: Navigating the Road to a Successful Transplant.Journal of the American Society of Nephrology : JASN · 2024Article
- Frailty and post-transplant adverse outcomes among kidney transplant recipients A systematic review and meta-analysis.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2024Article
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 16 institutions in 1 country.
Funding
Abstract
The construct of frailty was first developed in gerontology to help identify older adults with increased vulnerability when confronted with a health stressor. This article is a review of studies in which frailty has been applied to pre- and post-kidney transplantation (KT) populations. Although KT is the optimal treatment for end-stage kidney disease (ESKD), KT candidates often must overcome numerous health challenges associated with ESKD before receiving KT. After KT, the impacts of surgery and immunosuppression represent additional health stressors that disproportionately impact individuals with frailty. Frailty metrics could improve the ability to identify KT candidates and recipients at risk for adverse health outcomes and those who could potentially benefit from interventions to improve their frail status. The Physical Frailty Phenotype (PFP) is the most commonly used frailty metric in ESKD research, and KT recipients who are frail at KT (~20% of recipients) are twice as likely to die as nonfrail recipients. In addition to the PFP, many other metrics are currently used to assess pre- and post-KT vulnerability in research and clinical practice, underscoring the need for a disease-specific frailty metric that can be used to monitor KT candidates and recipients. Although frailty is an independent risk factor for post-transplant adverse outcomes, it is not factored into the current transplant program risk-adjustment equations. Future studies are needed to explore pre- and post-KT interventions to improve or prevent frailty.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.