Evidence map›Paper›PMID 32191172›Full record

ArticleBJPsych open2020

Transdiagnostic neurocognitive subgroups and functional course in young people with emerging mental disorders: a cohort study.

Jacob J Crouse, Kate M Chitty, Frank Iorfino, Joanne S Carpenter, Django White, Alissa Nichles, Natalia Zmicerevska, Ashleigh M Tickell, Rico S C Lee, Sharon L Naismith and 4 more

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In one paragraph

Article in BJPsych open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Transdiagnostic Clinical Staging in Youth Mental Health: A primer for clinical practice.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jacob J CrouseBrain and Mind Centre, University of Sydney, Australia.ORCID https://orcid.org/0000-0002-3805-2936
Kate M ChittyTranslational Australian Clinical Toxicology (TACT) Research Group, University of Sydney, NSW, Australia.
Frank IorfinoBrain and Mind Centre, University of Sydney, Australia; and InnoWell, Pty Ltd, Australia.
Joanne S CarpenterBrain and Mind Centre, University of Sydney, Australia.
Django WhiteThe Black Dog Institute, University of New South Wales, Australia.
Alissa NichlesBrain and Mind Centre, University of Sydney, Australia.
Natalia ZmicerevskaBrain and Mind Centre, University of Sydney, Australia.
Ashleigh M TickellBrain and Mind Centre, University of Sydney, Australia.
Rico S C LeeTurner Institute for Brain and Mental Health, Monash University, Australia.
Sharon L NaismithCharles Perkins Centre, University of Sydney; and Brain and Mind Centre, University of Sydney, Australia.
Elizabeth M ScottNotre Dame Medical School, University of Notre Dame, Australia.
Jan ScottAcademic Psychiatry, Institute of Neuroscience, Newcastle University, UK.ORCID https://orcid.org/0000-0002-7203-8601
Daniel F HermensSunshine Coast Mind and Neuroscience Thompson Institute, University of the Sunshine Coast, Australia.
Ian B HickieBrain and Mind Centre, University of Sydney, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeurocognitive impairments robustly predict functional outcome. However, heterogeneity in neurocognition is common within diagnostic groups, and data-driven analyses reveal homogeneous neurocognitive subgroups cutting across diagnostic boundaries.

aimsTo determine whether data-driven neurocognitive subgroups of young people with emerging mental disorders are associated with 3-year functional course.

methodModel-based cluster analysis was applied to neurocognitive test scores across nine domains from 629 young people accessing mental health clinics. Cluster groups were compared on demographic, clinical and substance-use measures. Mixed-effects models explored associations between cluster-group membership and socio-occupational functioning (using the Social and Occupational Functioning Assessment Scale) over 3 years, adjusted for gender, premorbid IQ, level of education, depressive, positive, negative and manic symptoms, and diagnosis of a primary psychotic disorder.

resultsCluster analysis of neurocognitive test scores derived three subgroups described as 'normal range' (n = 243, 38.6%), 'intermediate impairment' (n = 252, 40.1%), and 'global impairment' (n = 134, 21.3%). The major mental disorder categories (depressive, anxiety, bipolar, psychotic and other) were represented in each neurocognitive subgroup. The global impairment subgroup had lower functioning for 3 years of follow-up; however, neither the global impairment (B = 0.26, 95% CI -0.67 to 1.20; P = 0.581) or intermediate impairment (B = 0.46, 95% CI -0.26 to 1.19; P = 0.211) subgroups differed from the normal range subgroup in their rate of change in functioning over time.

conclusionsNeurocognitive impairment may follow a continuum of severity across the major syndrome-based mental disorders, with data-driven neurocognitive subgroups predictive of functional course. Of note, the global impairment subgroup had longstanding functional impairment despite continuing engagement with clinical services.

Indexed as

anxiety disordersdepressive disordersoutcome studiespsychotic disordersSocial functioning

Identifiers

PMID32191172
PMCPMC7176869

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.