Evidence map›Paper›PMID 32190985›Full record

ArticleESC heart failure2020

Comparing short-term outcome after implantation of the HeartWare® HVAD® and the Abbott® HeartMate 3®.

Rene Schramm, Armin Zittermann, Michiel Morshuis, Michael Schoenbrodt, Ellen von Roessing, Vera von Dossow, Andreas Koster, Henrik Fox, Kavous Hakim-Meibodi, Jan F Gummert

Abstract read
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

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  18. GMP-Compliant Radiosynthesis of [Pharmaceuticals (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rene SchrammClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Armin ZittermannClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Michiel MorshuisClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Michael SchoenbrodtClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Ellen von RoessingClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Vera von DossowInstitute of Anesthesiology, Heart and Diabetes Center North Rhine Westphalia, Bad Oeynhausen, Germany.
Andreas KosterInstitute of Anesthesiology, Heart and Diabetes Center North Rhine Westphalia, Bad Oeynhausen, Germany.
Henrik FoxClinic for Cardiology, Heart and Diabetes Center North Rhine Westphalia, Bad Oeynhausen, Germany.
Kavous Hakim-MeibodiClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.
Jan F GummertClinic for Thoracic and Cardiovascular Surgery, Heart and Diabetes Center North Rhine Westphalia, Georgstr. 11, D-32503, Bad Oeynhausen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsCentrifugal continuous flow pumps are currently the state of the art in left ventricular assist device therapy. This study was conducted to compare the results after implantation of the HVAD® and the HeartMate 3®. METHODS AND

resultsWe retrospectively analysed preoperative and post-operative patient data of all 106 patients, who received a HeartMate 3 (HM3) at our centre between 2014 and 2018. A total of 392 patients receiving a sintered HVAD® served as controls. Patient matching was performed for age, sex, Interagency Registry for Mechanically Assisted Circulatory Support level at the time of implant, perioperative right heart failure, and implantation strategy, that is, bridge to transplant or destination therapy, as well as preoperative renal function, that is, as indicated by serum creatinine levels. A total of 79 matched pairs could be identified. During a median follow-up of 15.3 months (range: 0-30 months), 23 (29.1%) and 19 (24.1%) patients died in the HVAD and HM3 groups, respectively, with a hazard ratio for mortality of 0.84 [95% confidence interval (CI): 0.46-1.54; P = 0.568]. Freedom from cerebrovascular events did not differ significantly between study groups, with a hazard ratio of 0.57 (95% CI: 0.23-1.45; P = 0.241). The risk of driveline infection was significantly lower in the HM3 (n = 33) than in the HVAD (n = 55) group (hazard ratio = 0.54; 95% CI: 0.35-0.84; P = 0.006). Eight HVAD, but no HM3, patients developed a pump thrombosis during follow-up (P = 0.148).

conclusionsPerformance of both currently used centrifugal left ventricular assist device systems is comparable in terms of short-term patient survival and freedom from cerebrovascular events. In our single-centre experience, HM3 patients less frequently develop driveline infections and no pump thrombosis, which requires further evaluation.

Indexed as

Heart-Assist DevicesHeart FailureThrombosisHumansRegistriesRetrospective StudiesCentrifugal continuous flow pumpLeft ventricular assist deviceMechanical circulatory support

Identifiers

PMID32190985
PMCPMC7261579

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.