ArticleAmerican journal of human biology : the official journal of the Human Biology Council2020
A missense variant in CREBRF is associated with taller stature in Samoans.
Article in American journal of human biology : the official journal of the Human Biology Council, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- A stop-gain variant inHGG advances · 2023Pooled it
- A scoping review on cardiometabolic risk factors among Pacific Island populations and implications on future research in the region.American journal of epidemiology · 2026Article
- The accuracy of polygenic score models for BMI and Type II diabetes in the Native Hawaiian population.Communications biology · 2025Article
- The impact of CREBRF rs373863828 Pacific-variant on infant body composition.Scientific reports · 2024Article
- Article
- Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries.Genetic epidemiology · 2023Article
- The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans.Obesity (Silver Spring, Md.) · 2022Article
- Limited Metabolic Effect of the CREBRFCells · 2022Article
- Body size and composition of Samoan toddlers aged 18-25 months in 2019.Annals of human biology · 2021Article
- Article
- The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity.Diabetologia · 2020Article
- Population-specific reference panels are crucial for genetic analyses: an example of the CREBRF locus in Native Hawaiians.Human molecular genetics · 2020Article
- The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.Obesity research & clinical practiceArticle
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 5 countries.
Funding
Abstract
objectivesStudies have demonstrated that rs373863828, a missense variant in CREBRF, is associated with a number of anthropometric traits including body mass index (BMI), obesity, percent body fat, hip circumference, and abdominal circumference. Given the biological relationship between height and adiposity, we hypothesized that the effect of this variant on BMI might be due in part to an association of this variant with height.
methodsWe tested the hypothesis that minor allele of rs373863828 is associated with height in a Samoan population in two adult cohorts and in a separate cohort of children (age 5-18 years old) using linear mixed modeling.
resultsWe found evidence of a strong relationship between rs373863828 and greater mean height in Samoan adults (0.77 cm greater average height for each copy of the minor allele) with the same direction of effect in Samoan children.
conclusionsThese results suggest that the missense variant rs373863828 in CREBRF, first identified through an association with larger BMI, may be related to an underlying biological mechanism affecting overall body size including stature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.