ArticleInflammatory bowel diseases2020
Introduction to and Screening Visit Results of the Multicenter Pediatric Crohn's Disease Growth Study.
Article in Inflammatory bowel diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Sex Differences in Growth Recovery among Children with Crohn's Disease.Gut and liver · 2026Article
- Reproductive Health in Young and Adolescent Females with Inflammatory Bowel Disease.Current gastroenterology reports · 2026Review
- Pediatric inflammatory bowel diseases: Effects of disease and treatment regimens on growth and puberty.Northern clinics of Istanbul · 2025Article
- Clinical Variables Associated With Statural Growth in Pediatric Crohn's Disease Differ by Sex (The Growth Study).Inflammatory bowel diseases · 2021Article
- Growth and Puberty in Children with Inflammatory Bowel Diseases.Biomedicines · 2020Review
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Authors and funding
10 authors.
Funding
Abstract
backgroundStatural growth impairment is more common in males with Crohn's disease (CD). We assessed sex differences in height Z score differences and bone age (BA) Z scores and characterized age of menarche in a novel contemporary cohort of pediatric CD patients undergoing screening for enrollment in the multicenter longitudinal Growth Study.
methodsCrohn's disease patients (females with chronological age [CA] 5 years and older and younger than 14 years; males with CA 6 years and older and younger than 16 years) participated in a screening visit for the Growth Study. Height BA-Z scores are height Z scores calculated based on BA. Height CA-Z scores are height Z scores calculated based on CA. The height Z score difference equals height CA-Z score minus height BA-Z score.
resultsOne hundred seventy-one patients (60% male) qualified for this analysis. Mean CA was 12.2 years. Mean height CA-Z score was -0.4, and mean height BA-Z score was 0.4 in females. Mean height CA-Z score was -0.1, and mean height BA-Z score was 0.2 in males. The absolute value of the mean height Z score difference was significantly greater in females (0.8) than males (0.3; P = 0.005). The mean BA-Z score in females (-1.0) was significantly lower than in males (-0.2; P = 0.002). The median CA at menarche was 13.6 (95% CI, 12.6-14.6) years.
conclusionsOur screening visit data suggest that standardized height gain is lower in males with skeletal maturation and delayed puberty is common in females in CD. We are investigating these findings in the ongoing Growth Study.
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