ArticleACS pharmacology & translational science2020
A new selective pharmacological enhancer of the Orai1 Ca
Open access · bronzeAbstract read
In one paragraph
Article in ACS pharmacology & translational science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.0field-weighted citation impact, top 11% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- A Quartet of Native Orai Channel Isoforms Orchestrates Graded NFAT Activation and Transcription.bioRxiv : the preprint server for biology · 2026Article
- The nonexcitable smooth muscle: remodeling the smooth muscle ion transport toolkit in disease.Physiological reviews · 2026Review
- STIM/Orai-Mediated Store-Operated CaCells · 2026Review
- Orai1 is Required for Osteogenic Differentiation on Nanoparticulate Mineralized Collagen Glycosaminoglycan Materials.Macromolecular bioscience · 2025Article
- Functional characterization of the store-operated calcium entry pathway in naked mole-rat cells.Open biology · 2025Article
- Altered Mitochondrial Bioenergetics and Calcium Kinetics in Young-Onset PLA2G6 Parkinson's Disease iPSCs.Journal of neurochemistry · 2025Article
- Store-Operated CaJournal of clinical medicine · 2023Review
- Neuronal Store-Operated Calcium Channels.Molecular neurobiology · 2023Review
- Orai, RyR, and IPCommunications biology · 2023Article
- Orai1 as a potential "fits-all approach" therapeutic target for the treatment of DMD.The Journal of general physiology · 2023Article
- ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Suppression of CaThe EMBO journal · 2022Article
- Piezo1-Regulated Mechanotransduction Controls Flow-Activated Lymphatic Expansion.Circulation research · 2022Article
- ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 Binding, Calcium Influx and Transcription Factor Translocation.International journal of molecular sciences · 2022Article
- Functional and structural differences between skinned and intact muscle preparations.The Journal of general physiology · 2022Review
- Deciphering Molecular Mechanisms and Intervening in Physiological and Pathophysiological Processes of CaCells · 2021Review
- Role of Store-Operated CaBiomolecules · 2021Review
- Review
- 1,2,4-Oxadiazole-Bearing Pyrazoles as Metabolically Stable Modulators of Store-Operated Calcium Entry.ACS medicinal chemistry letters · 2021Article
- SOCE in the cardiomyocyte: the secret is in the chambers.Pflugers Archiv : European journal of physiology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 3 countries.
Iman AzimiDivision of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, Tasmania 7001, Australia.
Ralph J StevensonAuckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Auckland, 1142, New Zealand.
Xuexin ZhangDepartment of Cellular and Molecular Physiology, and Pennsylvania State Cancer Institute. The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Aldo Meizoso-HuescaSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
Ping XinDepartment of Cellular and Molecular Physiology, and Pennsylvania State Cancer Institute. The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Martin JohnsonDepartment of Cellular and Molecular Physiology, and Pennsylvania State Cancer Institute. The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Jack U FlanaganAuckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Auckland, 1142, New Zealand.
Silke B ChalmersSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
Ryan E YoastDepartment of Cellular and Molecular Physiology, and Pennsylvania State Cancer Institute. The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Jeevak S KapureSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
Benjamin P RossSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
Irina VetterSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
Mark R AshtonUniQuest Pty Ltd, The University of Queensland, Brisbane, Queensland 4072, Australia.
Bradley S LaunikonisSchool of Biomedical Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.
William A DennyAuckland Cancer Society Research Centre, School of Medical Sciences, The University of Auckland, Auckland, 1142, New Zealand.
Mohamed TrebakDepartment of Cellular and Molecular Physiology, and Pennsylvania State Cancer Institute. The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Gregory R MonteithSchool of Pharmacy, The University of Queensland, Brisbane 4072, Queensland, Australia.
The University of Queensland · AUPennsylvania State University · USUniversity of Auckland · NZTranslational Research Institute · AUUniversity of Tasmania · AU
Funding
Ca2+ Signaling Networks in Health and DiseaseR35HL150778 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TREBAK, MOHAMED · 2020 to 2025
$5.4MReceptor-regulated Ca2+ Entry Pathways in Smooth MuscleR01HL097111 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2010 to 2019
$3.7MLeukotriene C4 and STIM/Orai channels in airway smooth muscle remodelingR01HL123364 · NHLBI · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI TREBAK, MOHAMED · 2014 to 2017
$1.5MThe Mitochondrial Sodium/Calcium Exchanger (NCLX) in Airway Smooth Muscle Remodeling during AsthmaF30HL147489 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI JOHNSON, MARTIN T · 2019 to 2022
$149kNHLBI NIH HHS F30 HL147489NHLBI NIH HHS R01 HL097111NHLBI NIH HHS R01 HL123364NHLBI NIH HHS R35 HL150778
Abstract
Store operated calcium (Ca
Indexed as
Ca2+ influxenhancerOrai1skeletal musclesmooth muscle
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.