Evidence map›Paper›PMID 32190787›Full record

ArticleTranslational medicine of aging2019

Rb analog Whi5 regulates G1 to S transition and cell size but not replicative lifespan in budding yeast.

Matthew M Crane, Mitsuhiro Tsuchiya, Ben W Blue, Jared D Almazan, Kenneth L Chen, Siobhan R Duffy, Alexandra Golubeva, Annaiz M Grimm, Alison M Guard, Shauna A Hill and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational medicine of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Matthew M CraneDepartment of Pathology, University of Washington, Seattle, WA, USA.
Mitsuhiro TsuchiyaDepartment of Pathology, University of Washington, Seattle, WA, USA.
Ben W BlueDepartment of Pathology, University of Washington, Seattle, WA, USA.
Jared D AlmazanDepartment of Pathology, University of Washington, Seattle, WA, USA.
Kenneth L ChenDepartment of Pathology, University of Washington, Seattle, WA, USA.
Siobhan R DuffyDepartment of Pathology, University of Washington, Seattle, WA, USA.
Alexandra GolubevaDepartment of Pathology, University of Washington, Seattle, WA, USA.
Annaiz M GrimmDepartment of Pathology, University of Washington, Seattle, WA, USA.
Alison M GuardDepartment of Pathology, University of Washington, Seattle, WA, USA.
Shauna A HillDepartment of Pathology, University of Washington, Seattle, WA, USA.
Ellen HuynhDepartment of Pathology, University of Washington, Seattle, WA, USA.
Ryan M KellyDepartment of Pathology, University of Washington, Seattle, WA, USA.
Michael KiflezghiDepartment of Pathology, University of Washington, Seattle, WA, USA.
Hyunsung D KimDepartment of Pathology, University of Washington, Seattle, WA, USA.
Mitchell LeeDepartment of Pathology, University of Washington, Seattle, WA, USA.
Ting-I LeeDepartment of Pathology, University of Washington, Seattle, WA, USA.
Jiayi LiDepartment of Pathology, University of Washington, Seattle, WA, USA.
Bao M G NguyenDepartment of Pathology, University of Washington, Seattle, WA, USA.
Riley M WhalenDepartment of Pathology, University of Washington, Seattle, WA, USA.
Feng Y YehDepartment of Pathology, University of Washington, Seattle, WA, USA.
Mark McCormickDepartment of Biochemistry and Molecular Biology, University of New Mexico, Albuquerque, NM, USA.
Brian K KennedyBuck Institute for Research on Aging, Novato, CA, USA.
Joe R DelaneyDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, USA.
Matt KaeberleinDepartment of Pathology, University of Washington, Seattle, WA, USA.
University of Washington · USBuck Institute for Research on Aging · USMedical University of South Carolina · USUniversity of New Mexico · US

Funding

SPECIFICITY OF OXYGEN DNA DAMAGE AND MUTAGENESISP01AG001751 · NIA · UNIVERSITY OF WASHINGTON · PI PRUSKY, GLEN THOMAS · 1985 to 2021
$29.6M
University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
Unfolded Protein Response and Autophagy in T Helper Cell Effector FunctionP20GM121176 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Monica Rosas Lemus · 2017 to 2026
$24.9M
GENETIC APPROACHES TO AGING RESEARCHT32AG000057 · NIA · UNIVERSITY OF WASHINGTON · PI RABINOVITCH, PETER S · 1985 to 2019
$14.2M
Emergent properties of signaling network degradation that mediate homeostatic failure during agingR01AG056359 · NIA · UNIVERSITY OF WASHINGTON · PI KAEBERLEIN, MATT, VILLEN, JUDIT · 2017 to 2021
$2.9M
NIA NIH HHS P01 AG001751NIA NIH HHS P30 AG013280NIA NIH HHS R01 AG056359NIA NIH HHS T32 AG000057NIGMS NIH HHS P20 GM121176
6 · The paper itself

Abstract

An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid

Identifiers

PMID32190787
PMCPMC7080187
OpenAlexW2986317167

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.