Evidence map›Paper›PMID 32190784›Full record

ArticleNanoImpact2020

Effects of ingested nanocellulose on intestinal microbiota and homeostasis in Wistar Han rats.

Sangeeta Khare, Glen M DeLoid, Ramon M Molina, Kuppan Gokulan, Sneha P Couvillion, Kent J Bloodsworth, Elizabeth K Eder, Allison R Wong, David W Hoyt, Lisa M Bramer and 4 more

Open access · greenAbstract read
In one paragraph

Article in NanoImpact, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 77 citations in OpenAlex.

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  17. Toxicity, uptake, and nuclear translocation of ingested micro-nanoplastics in an in vitro model of the small intestinal epithelium.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Sangeeta KhareDivision of Microbiology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR 72079, USA.
Glen M DeLoidCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Ramon M MolinaCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Kuppan GokulanDivision of Microbiology, National Center for Toxicological Research, U.S. Food & Drug Administration, Jefferson, AR 72079, USA.
Sneha P CouvillionBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Kent J BloodsworthBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Elizabeth K EderEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA.
Allison R WongEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA.
David W HoytEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA, USA.
Lisa M BramerComputing & Analytics Division, Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA.
Thomas O MetzBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Brian D ThrallBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Joseph D BrainCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Philip DemokritouCenter for Nanotechnology and Nanotoxicology, Department of Environmental Health, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
Pacific Northwest National Laboratory · USHarvard University · USEnvironmental Molecular Sciences Laboratory · USNational Center for Toxicological Research · USUnited States Food and Drug Administration · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Engineered Nanomaterial Synthesis, Characterization and Method Development Center for Nano-safety ResearchU24ES026946 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI DEMOKRITOU, PHILIP · 2016 to 2020
$3.8M
Key Events in Modulation of Lung Infection Susceptibility by NanomaterialsU01ES027292 · NIEHS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI QIAN, WEI-JUN · 2016 to 2020
$2.0M
NIEHS NIH HHS P30 ES000002NIEHS NIH HHS U01 ES027292NIEHS NIH HHS U24 ES026946
6 · The paper itself

Abstract

Micron scale cellulose materials are "generally regarded as safe" (GRAS) as binders and thickeners in food products. However, nanocellulose materials, which have unique properties that can improve food quality and safety, have not received US-Food and Drug Administration (FDA) approval as food ingredients.

Indexed as

ingested nanomaterialintestinal permeabilityin vivometabolomemicrobiomenanocelluloseratrisk assessment

Identifiers

PMID32190784
PMCPMC7080203
OpenAlexW3007307270

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.