Evidence map›Paper›PMID 32190695›Full record

ArticleJournal of diabetes research2020

Identification of Potential Serum Metabolic Biomarkers of Diabetic Kidney Disease: A Widely Targeted Metabolomics Study.

Hang Zhang, Jing-Jing Zuo, Si-Si Dong, Yuan Lan, Chen-Wei Wu, Guang-Yun Mao, Chao Zheng

Abstract read
In one paragraph

Article in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Urinary biomarkers of diabetic kidney disease.World journal of diabetes · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Integrated multiomic analyses: An approach to improve understanding of diabetic kidney disease.Diabetic medicine : a journal of the British Diabetic Association · 2025
    Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Application of Metabolomics and Traditional Chinese Medicine for Type 2 Diabetes Mellitus Treatment.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hang ZhangDiabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou, China.
Jing-Jing ZuoCenter on Clinical Research, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0001-6093-2684
Si-Si DongDiabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou, China.
Yuan LanCenter on Clinical Research, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.
Chen-Wei WuDiabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou, China.ORCID https://orcid.org/0000-0001-7255-7615
Guang-Yun MaoCenter on Clinical Research, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-4548-7524
Chao ZhengDiabetes Center and Department of Endocrinology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, No. 109 West Xueyuan Road, Wenzhou, China.ORCID https://orcid.org/0000-0002-1942-8854

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

resultA total of 11 differential metabolites, including Hexadecanoic Acid (C16:0), Linolelaidic Acid (C18:2N6T), Linoleic Acid (C18:2N6C), Trans-4-Hydroxy-L-Proline, 6-Aminocaproic Acid, L-Dihydroorotic Acid, 6-Methylmercaptopurine, Piperidine, Azoxystrobin Acid, Lysopc 20:4, and Cuminaldehyde, were determined as the potential biomarkers for the DKD early identification, based on the multivariable generalized linear regression model and receiver operating characteristic analysis.

conclusionSerum metabolites might act as sensitive and specific biomarkers for DKD early detection. Further longitudinal studies are needed to confirm our findings.

Indexed as

AgedBiomarkersCase-Control StudiesDiabetes Mellitus, Type 2Diabetic NephropathiesEarly DiagnosisFemaleHumansMaleMetabolomicsMiddle AgedTandem Mass SpectrometryBiomarkers

Identifiers

PMID32190695
PMCPMC7072115

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.