ReviewCureus2020
The Neuroprotective Effects of Exercise on Cognitive Decline: A Preventive Approach to Alzheimer Disease.
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05827276 (Effects of the Life Story Questionnaire on Physical Therapy Participation in Patients With Dementia), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of the Life Story Questionnaire on Physical Therapy Participation in Patients With Dementia: A Randomized Control Trial
Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- Amyloid pathology and modifiable risk factors in cognitive decline among cognitively unimpaired older adults.The journal of prevention of Alzheimer's disease · 2026Article
- Threshold effects of physical activity and cognitive function among older adults with diabetes mellitus in NHANES 2011-2014.Aging clinical and experimental research · 2025Article
- Potential therapeutic effects of Ebixa,Frontiers in neuroscience · 2025Article
- Computational Design of Novel Tau-Tubulin Kinase 1 Inhibitors for Neurodegenerative Diseases.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Exploring the neuroprotective role of physical activity in cerebral small vessel disease.Brain research · 2024Review
- Exercise Intervention for Alzheimer's Disease: Unraveling Neurobiological Mechanisms and Assessing Effects.Life (Basel, Switzerland) · 2023Review
- Article
- How to Prevent and/or Revert Alzheimer's Disease Continuum During Preclinical Phases.Journal of Alzheimer's disease reports · 2023Review
- Correlation between parameters related to sarcopenia and gray matter volume in patients with mild to moderate Alzheimer's disease.Aging clinical and experimental research · 2022Article
- The Therapeutic Role of Exercise and Probiotics in Stressful Brain Conditions.International journal of molecular sciences · 2022Review
- Movement as a Positive Modulator of Aging.International journal of molecular sciences · 2021Review
- Article
- Ginseng gintonin, aging societies, and geriatric brain diseases.Integrative medicine research · 2021Review
- [Exercise and physical training as interventions in gerontopsychiatry].Zeitschrift fur Gerontologie und Geriatrie · 2020Review
- How TRPC Channels Modulate Hippocampal Function.International journal of molecular sciences · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alzheimer's disease (AD) is a progressive disorder that causes brain cells to slowly degenerate and die. This leads to a continuous decline in thinking, behavioral and social skills that disrupts a person's ability to function independently. AD is the most common cause of dementia globally. Neuroinflammation caused by intracellular neurofibrillary tangles and extracellular amyloid deposits leads to atrophy of brain cells especially the hippocampus, which is associated with memory formation. This atrophy leads to dementia and cognitive decline. Among the many preventive factors being studied, exercise is thought to play a vital role in not only preventing the pre-clinical stage of AD but also slowing the clinical progression of AD. It is also deployed as a treatment option for late-stage AD along with pharmacological treatment options. Various studies and clinical trials in both human and animal models are of the opinion that exercise slows the onset and progression of cognitive decline in AD patients. Some studies suggest that this effect is due to a decrease in neurofibrillary tangles and amyloid deposits in brain parenchyma. Others suggest that exercise causes an increase in angiogenesis, neurogenesis, and synaptogenesis mainly due to an increase in blood flow, brain-derived neurotrophic factor (BDNF), insulin-like growth factor 1 (IGF-1), hormones, and second messengers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.