Evidence map›Paper›PMID 32190266›Full record

ArticleChemical science2020

Diminished viability of human ovarian cancer cells by antigen-specific delivery of carbon monoxide with a family of photoactivatable antibody-photoCORM conjugates.

Brian Kawahara, Lucy Gao, Whitaker Cohn, Julian P Whitelegge, Suvajit Sen, Carla Janzen, Pradip K Mascharak

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The Triple Crown: NO, CO, and HPharmacology & therapeutics · 2023
    Review
  8. Article
  9. Article
  10. Heme Oxygenase/Carbon Monoxide Participates in the Regulation ofInternational journal of molecular sciences · 2022
    Article
  11. Review
  12. Review
  13. Article
  14. Manganese(I) tricarbonyl complexes as potential anticancer agents.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Brian KawaharaDepartment of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA . Email: pradip@ucsc.edu.
Lucy GaoPasarow Mass Spectrometry Laboratory , Jane and Terry Semel Institute for Neuroscience and Human Behavior , University of California at Los Angeles , Los Angeles , CA 90095 , USA.
Whitaker CohnPasarow Mass Spectrometry Laboratory , Jane and Terry Semel Institute for Neuroscience and Human Behavior , University of California at Los Angeles , Los Angeles , CA 90095 , USA.
Julian P WhiteleggePasarow Mass Spectrometry Laboratory , Jane and Terry Semel Institute for Neuroscience and Human Behavior , University of California at Los Angeles , Los Angeles , CA 90095 , USA.
Suvajit SenDepartment of Obstetrics and Gynecology , David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA 90095 , USA.
Carla JanzenDepartment of Obstetrics and Gynecology , David Geffen School of Medicine , University of California at Los Angeles , Los Angeles , CA 90095 , USA.
Pradip K MascharakDepartment of Chemistry and Biochemistry , University of California , Santa Cruz , CA 95064 , USA . Email: pradip@ucsc.edu.ORCID 0000-0002-7044-944X
University of California, Los Angeles · USUniversity of California, Santa Cruz · US

Funding

Imaging Innovations for Placental Assessment in Response to Environmental PollutionU01HD087221 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DEVASKAR, SHERIN U, JANZEN, CARLA · 2015 to 2015
$4.3M
NICHD NIH HHS U01 HD087221
6 · The paper itself

Abstract

Carbon monoxide (CO)-releasing antibody conjugates were synthesized utilizing a photoactivatable CO-releasing molecule (photoCORM) and mouse monoclonal antibodies linked by a biotin-streptavidin system. Different monoclonal antibodies raised against different surface-expressed antigens that are implicated in ovarian cancer afforded a family of antibody-photoCORM conjugates (Ab-photoCORMs). In an immunosorbent/cell viability assay, Ab-photoCORMs accumulated onto ovarian cancer cells expressing the target antigens, delivering cytotoxic doses of CO

Identifiers

PMID32190266
PMCPMC7067254
OpenAlexW2989898929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.