Evidence map›Paper›PMID 32190252›Full record

ArticleChemical science2019

Solid-phase synthesis and structural characterisation of phosphoroselenolate-modified DNA: a backbone analogue which does not impose conformational bias and facilitates SAD X-ray crystallography.

Patrick F Conlon, Olga Eguaogie, Jordan J Wilson, Jamie S T Sweet, Julian Steinhoegl, Klaudia Englert, Oliver G A Hancox, Christopher J Law, Sarah A Allman, James H R Tucker and 2 more

Abstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Patrick F ConlonSchool of Chemistry and Chemical Engineering , Queen's University Belfast , David Keir Building, Stranmillis Road , Belfast , BT9 5AG , UK . Email: j.vyle@qub.ac.uk.ORCID 0000-0002-8756-9165
Olga EguaogieSchool of Chemistry and Chemical Engineering , Queen's University Belfast , David Keir Building, Stranmillis Road , Belfast , BT9 5AG , UK . Email: j.vyle@qub.ac.uk.ORCID 0000-0002-5822-5726
Jordan J WilsonSchool of Chemistry and Chemical Engineering , Queen's University Belfast , David Keir Building, Stranmillis Road , Belfast , BT9 5AG , UK . Email: j.vyle@qub.ac.uk.ORCID 0000-0002-7617-2736
Jamie S T SweetSchool of Chemistry and Chemical Engineering , Queen's University Belfast , David Keir Building, Stranmillis Road , Belfast , BT9 5AG , UK . Email: j.vyle@qub.ac.uk.ORCID 0000-0002-5291-3974
Julian SteinhoeglReading School of Pharmacy , University of Reading , Whiteknights , Reading RG6 6AP , UK . Email: james.hall@reading.ac.uk.ORCID 0000-0003-4323-8556
Klaudia EnglertSchool of Chemistry , University of Birmingham , Edgbaston , Birmingham B15 2TT , UK.
Oliver G A HancoxReading School of Pharmacy , University of Reading , Whiteknights , Reading RG6 6AP , UK . Email: james.hall@reading.ac.uk.ORCID 0000-0003-1801-1851
Christopher J LawSchool of Biological Sciences , Queen's University Belfast , 15 Chlorine Gardens , Belfast BT9 5AH , UK.
Sarah A AllmanReading School of Pharmacy , University of Reading , Whiteknights , Reading RG6 6AP , UK . Email: james.hall@reading.ac.uk.ORCID 0000-0003-4904-4138
James H R TuckerSchool of Chemistry , University of Birmingham , Edgbaston , Birmingham B15 2TT , UK.ORCID 0000-0001-7645-0815
James P HallReading School of Pharmacy , University of Reading , Whiteknights , Reading RG6 6AP , UK . Email: james.hall@reading.ac.uk.ORCID 0000-0003-3716-4378
Joseph S VyleSchool of Chemistry and Chemical Engineering , Queen's University Belfast , David Keir Building, Stranmillis Road , Belfast , BT9 5AG , UK . Email: j.vyle@qub.ac.uk.ORCID 0000-0001-8792-6436

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oligodeoxynucleotides incorporating internucleotide phosphoroselenolate linkages have been prepared under solid-phase synthesis conditions using dimer phosphoramidites. These dimers were constructed following the high yielding Michaelis-Arbuzov (M-A) reaction of nucleoside

Identifiers

PMID32190252
PMCPMC7066676

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.