Evidence map›Paper›PMID 32190127›Full record

ArticleJournal of genomics2020

Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes.

Aditi Kulkarni, Wanqin Yu, Alex S Moon, Ashmita Pandey, Kathryn A Hanley, Jiannong Xu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aditi KulkarniDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
Wanqin YuDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
Alex S MoonDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
Ashmita PandeyDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
Kathryn A HanleyDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
Jiannong XuDepartment of Biology, New Mexico State University, PO Box 30001 MSC 3AF, Las Cruces NM, 88003, USA.
New Mexico State University · US

Funding

NM-INBRE Sequencing and Bioinformatics CoreP20GM103451 · NIGMS · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI Charlotte C. Gard · 2012 to 2026
$61.2M
Bacterial colonization and immunogenicity in the mosquito gut ecosystemSC1AI112786 · NIAID · NEW MEXICO STATE UNIVERSITY LAS CRUCES · PI XU, JIANNONG · 2014 to 2017
$1.3M
NIAID NIH HHS SC1 AI112786NIGMS NIH HHS P20 GM103451
6 · The paper itself

Abstract

In the CRISPR-Cas systems, Cas13a is an RNA-guided RNA nuclease specifically targeting single strand RNA. We developed a Cas13a mediated CRISPR interference tool to target mRNA for gene silencing in mosquitoes. A

Indexed as

Aedes aegyptiAnopheles gambiaeCRISPR-Cas13aCRISPRigene silencingRNA interference

Identifiers

PMID32190127
PMCPMC7064736
OpenAlexW3007317106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.