Evidence map›Paper›PMID 32190034›Full record

ArticleAdvanced functional materials2019

Wei Zhu, Chengyan Chu, Shreyas Kuddannaya, Yue Yuan, Piotr Walczak, Anirudha Singh, Xiaolei Song, Jeff W M Bulte

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Biodegradable Elastomers and Gels for Elastic Electronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022
    Review
  19. Review
  20. In Vivo Imaging of Implanted Hyaluronic Acid Hydrogel Biodegradation.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei ZhuRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Chengyan ChuRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Shreyas KuddannayaRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Yue YuanRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Piotr WalczakRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Anirudha SinghDepartment of Urology, the James Buchanan Brady Urological Institute, the Johns Hopkins University School of Medicine, Baltimore, MD, 21287.
Xiaolei SongRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Jeff W M BulteRussell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, the Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.

Funding

Training/Dissemination-Resource for Molecular Imaging Agents in Precision MedicineP41EB024495 · NIBIB · UT SOUTHWESTERN MEDICAL CENTER · PI MARTIN G POMPER · 2017 to 2026
$11.8M
Label-Free Imaging of Composite Hyaluronic Acid Hydrogels in Regenerative MedicineR01EB023647 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI BULTE, JEFF W. · 2017 to 2020
$1.5M
A Durable and Urine-Leakage Resistive Tissue Engineered Urinary DiversionR21EB026711 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI SINGH, ANIRUDHA · 2018 to 2020
$655k
Combined Optical/Micro-CT ScannerS10OD010744 · OD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI BULTE, JEFF W. · 2012 to 2012
$599k
NIBIB NIH HHS P41 EB024495NIBIB NIH HHS R01 EB023647NIBIB NIH HHS R21 EB026711NIH HHS S10 OD010744
6 · The paper itself

Abstract

Hydrogel scaffolding of stem cells is a promising strategy to overcome initial cell loss and manipulate cell function post-transplantation. Matrix degradation is a requirement for downstream cell differentiation and functional tissue integration, which determines therapeutic outcome. Therefore, monitoring of hydrogel degradation is essential for scaffolded cell replacement therapies. We show here that chemical exchange saturation transfer magnetic resonance imaging (CEST MRI) can be used as a label-free imaging platform for monitoring the degradation of crosslinked hydrogels containing gelatin (Gel) and hyaluronic acid (HA), of which the stiffness can be fine-tuned by varying the ratio of the Gel:HA. By labeling Gel and HA with two different NIR dyes having distinct emission excitation frequencies, we show here that the HA signal remains stable for 42 days, while the Gel signal gradually decreases to <25% of its initial value at this time point. Both imaging modalities were in excellent agreement for both the time course and relative value of CEST MRI and NIR signals (R

Indexed as

biodegradationCEST MRIgelatinhyaluronic acidhydrogelNIR imaging

Identifiers

PMID32190034
PMCPMC7079757

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.