Evidence map›Paper›PMID 32189934›Full record

ReviewJournal of clinical and experimental hepatology

Cost-Effectiveness Analysis and Decision Modelling: A Tutorial for Clinicians.

Nidhi Gupta, Rohan Verma, Radha K Dhiman, Kavitha Rajsekhar, Shankar Prinja

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of clinical and experimental hepatology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07387393 (Peau o le Vasa), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07387393 naenrolling by invitationnot on this map

Peau o le Vasa: Accelerating the Currents of Health Advances for Pasifika People

TypeinterventionalSponsorUniversity of HawaiiRan2026 to 2028Enrolled400ConditionsCardiometabolic Conditions, Hypertension (HTN), Dyslipidemia, Pre-diabetesArmsPILI (Partnership for Improving Lifestyle Intervention) Pasifika Program
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Contamination Rates and Economic Evaluation of Reusing Medicated, Preservative-Free, Single-Use Eye Drops.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
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  13. Article
  14. Markov modeling for cost-effectiveness using federated health data network.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  15. Article
  16. Article
  17. Economic analyses in cardiac electrophysiology: from clinical efficacy to cost utility.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nidhi GuptaDepartment of Radiation Oncology, Government Medical College and Hospital, Chandigarh, India.
Rohan VermaSchool of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Radha K DhimanDepartment of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Kavitha RajsekharDepartment of Health Research, Ministry of Health and Family Welfare, Government of India.
Shankar PrinjaSchool of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cost-effectiveness analysis (CEA) provides information on how much extra do we need to spend per unit gain in health outcomes with introduction of any new healthcare intervention or treatment as compared to the alternative. This information is crucial to make decision regarding funding any new drug, diagnostic test or determining standard treatment protocol. It becomes even more important to consider this evidence in resource constrained low-income and middle-income country settings. Generating evidence on costs and consequences of a treatment or intervention could be performed in the setting of a randomized controlled trial, which is the perfect platform to evaluate efficacy or effectiveness. However, we argue that randomized controlled trial (RCT) offers an incomplete setting to generate comprehensive data on all costs and consequences for the purpose of a CEA. Hence, it is needed to use a decision model, either in combination with the evidence from RCT or alone. In this article, we demonstrate the application of decision model-based economic evaluation using 2 separate techniques - a decision tree and a Markov model. We argue that application of a decision model allows computation of health benefits in terms of utility-based measure such as a quality-adjusted life year or disability-adjusted life year which is preferred for a CEA, measure distal costs and consequences which are much more downstream to the application of intervention, allows comparison with multiple intervention and comparators, and provides opportunity of making use of evidence from multiple sources rather than a single RCT which may have limited generalizability. This makes the use of such evidence much more acceptable for clinical use and policy relevant.

Indexed as

BCLC, Barcelona Clinic Liver CancerBSC, Best Supportive CareCAD, Coronary Artery DiseaseCEA, Cost-Effectiveness Analysiscost-effectivenessDALY, Disability Adjusted Life Yeardecision modeldecision treeeconomic evaluationEE, Economic EvaluationHCC, Hepatocellular CarcinomaHCV, Hepatitis C VirusHib, Hemophilus InfluenzaHPV, Human PapillomavirusICER, Incremental Cost-Effectiveness Ratiomarkov modelPD, Progressive DiseasePFS, Progression-Free StateQALY, Quality Adjusted Life YearRCT, Randomized controlled trialSNCU, Special Newborn Care Unit

Identifiers

PMID32189934
PMCPMC7068010

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.