ReviewMedical gas research
Ozonated oil in wound healing: what has already been proven?
Review in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05620550 (Evaluation of the Effect of Ozonated Oil on the Healing of Palatal Donor Area of Free Gingival Grafts.), which is not on this map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Effect of Ozonated Oil on the Healing of Palatal Donor Area of Free Gingival Grafts.
Who cites it
28 citing papers in PubMed.
- Effects of topical ozonated olive oil on lipid profile, quality of life, wound healing and glycemic control in patients with diabetic foot ulcers: a randomized controlled trial.Lipids in health and disease · 2025Trial
- Evaluation of a Commercial Ozonated Olive Oil Product (800 mEq OPathogens (Basel, Switzerland) · 2026Article
- Topical Ozone as an Adjuvant Therapy in Wound Management: An Integrative Review.Nursing reports (Pavia, Italy) · 2025Review
- Physico-Chemical and Antimicrobial Evaluation of Ozonated Olive Oil Produced with a Medical-Grade Generator for Veterinary Purposes.Microorganisms · 2025Article
- Nanocarriers for Medical Ozone Delivery: A New Therapeutic Strategy.Nanomaterials (Basel, Switzerland) · 2025Review
- Management of neurotrophic corneal ulcer with a topical liposomal ozonated oil: A report on three clinical cases.American journal of ophthalmology case reports · 2025Article
- Ozonated Sunflower Oil Stimulates the Local Antioxidant System and Helps Meglumine Antimoniate to Ameliorate Cutaneous Leishmaniasis Lesions.ACS omega · 2025Article
- Ozonated Olive Oil Dressing for Pediatric Hypospadias Repair: A Prospective Randomized Clinical Trial.Children (Basel, Switzerland) · 2025Article
- Review
- Evaluating the therapeutic efficacy of ozone liquid dressing in healing wounds associated with bullous pemphigoid.Scientific reports · 2025Article
- The Antifungal Potential of Ozonated Extra-Virgin Olive Oil AgainstBiomolecules · 2024Article
- The Efficacy of Ozonated Olive Oil in Crown Lengthening Procedures for Anterior Teeth: A Case Report.Cureus · 2024Article
- A Comparative Study of the Chemical Properties and Antibacterial Activity of Four Different Ozonated Oils for Veterinary Purposes.Veterinary sciences · 2024Article
- Topical application of ozonated sunflower oil accelerates the healing of lesions of cutaneous leishmaniasis in mice under meglumine antimoniate treatment.Medical microbiology and immunology · 2024Article
- Article
- The Role of Ozonated Jerusalem Artichoke Ointment on the Healing of Surgically Created Full-Thickness Cutaneous Wounds in Rabbits.Veterinary medicine international · 2024Article
- Effects of ozone therapy applied topically, by bagging, or both on the healing of clean wounds induced in rat's skin.Acta cirurgica brasileira · 2024Article
- Ozone therapy improves early stages of osseointegration in ovariectomized rats.Journal of applied oral science : revista FOB · 2024Article
- Ozonated Sunflower Oil Exerted Potent Anti-Inflammatory Activities with Enhanced Wound Healing and Tissue Regeneration Abilities against Acute Toxicity of Carboxymethyllysine in Zebrafish with Improved Blood Lipid Profile.Antioxidants (Basel, Switzerland) · 2023Article
- Topical Hyperbaric Oxygen Therapy Versus Local Ozone Therapy in Healing of Venous Leg Ulcers.International journal of environmental research and public health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute or chronic inflammatory reactions aim to control lesions, resist to pathogens attack and repair damaged tissue. The therapeutic administration of ozone known as ozone therapy appears as a possible treatment for tissue repair, as it promotes the healing of wounds. It has bactericidal, antiviral and antifungal properties and has been used as a therapeutic resource to treat inflammation. The objective was to carry out an integrative review regarding the use of ozonated oil in acute and chronic inflammations. The keywords "ozone therapy," "inflammation" and "ozone" were used in the Portuguese, Spanish and English languages. The paper selection was based on inclusion and exclusion criteria. In total, 28 articles were selected. It has been seen that ozonated oil is effective in healing cutaneous wounds. The beneficial effects are due to the healing of wounds, due to the reduction of microbial infection, debridement effect, modulation of the inflammatory phase, stimulation to angiogenesis as well as biological and enzymatic reactions that favor the oxygen metabolism, improving the wound cicatrization. In addition to promoting healing, ozonated oil reduces symptoms related to skin burns, prevents post-lesion hyperpigmentation, and reduces the pain of aphthous ulcers. Therefore, ozonated oil represents an effective and inexpensive therapeutic alternative that must be implanted in the public health system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.