Trial reportMedical gas research
Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial.
Trial report in Medical gas research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Bibliometric analysis of research trends on hyperbaric oxygen therapy in stroke from 2000 to 2022.Frontiers in neurology · 2025Pooled it
- How completely are randomized controlled trials of non-pharmacological interventions following concussion reported? A systematic review.Journal of sport and health science · 2024Pooled it
- Systematic review and dosage analysis: hyperbaric oxygen therapy efficacy in the treatment of posttraumatic stress disorder.Frontiers in neurology · 2024Pooled it
- Adverse effects of hyperbaric oxygen therapy: a systematic review and meta-analysis.Frontiers in medicine · 2023Pooled it
- Systematic Review and Dosage Analysis: Hyperbaric Oxygen Therapy Efficacy in Mild Traumatic Brain Injury Persistent Postconcussion Syndrome.Frontiers in neurology · 2022Pooled it
- Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial.Scientific reports · 2022Trial
- Article
- Mild hyperbaric oxygen therapy on subjective sleep quality, aerobic, anaerobic exercise test, brain and muscle tissue oxygenation response in Chinese University male athletes after muscle fatigue.BMC sports science, medicine & rehabilitation · 2026Article
- Hyperbaric oxygen therapy (HBOT) for neurocognitive deficits following traumatic brain injury: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2025Article
- Prognostic value of CRP, PCT, and TNF-a, D-lactate, DAO, and endotoxin on survival of patients with severe craniocerebral injury.Journal of medical biochemistry · 2025Article
- Hyperbaric oxygen therapy for paroxysmal sympathetic hyperactivity syndrome after brain injury: a multicenter, retrospective cohort study.Medical gas research · 2025Observational
- Hyperbaric Oxygen Therapy (HBOT) in Moderate Traumatic Brain Injury (TBI): A Randomized Controlled Trial.Asian journal of neurosurgery · 2025Article
- Case Report: Low pressure hyperbaric oxygen therapy as a potential alternative treatment for chronic inflammatory response syndrome: a case study with notable improvements in fatigue, cognition, and testing.Frontiers in immunology · 2025Article
- Evaluating the Impact of Hyperbaric Oxygen Therapy and Neurofeedback on Mild Traumatic Brain Injury: A Case Report.Cureus · 2025Article
- Hyperbaric Oxygen Therapy in Children with Brain Injury: A Retrospective Case Series.International journal of medical sciences · 2025Article
- The Role of Hyperbaric Oxygen Therapy in Neuroregeneration and Neuroprotection: A Review.Cureus · 2024Review
- Review
- Hyperbaric oxygen therapy for poststroke insomnia: a systematic review and meta-analysis protocol.BMJ open · 2024Article
- Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma.Journal of nanobiotechnology · 2024Review
- Effects of hyperbaric oxygen combined cabin ventilator on critically ill patients with liberation difficulty after tracheostomy.Biomedical engineering online · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Persistent postconcussion syndrome (PPCS) after mild traumatic brain injury (mTBI) is a significant public health and military problem for which there is limited treatment evidence. The aim of this study was to determine whether forty 150 kPa hyperbaric oxygen therapies (HBOTs) can improve symptoms and cognitive function in subjects with the PPCS of mTBI, using a randomized controlled crossover design with 2-month follow-up. Sixty-three civilian and military subjects with mTBI/PPCS were randomized to either 40 HBOTs at 150 kPa/60 minutes, once daily, 5 days per week in 8 weeks or an equivalent no-treatment control period. The Control Group was then crossed over to HBOT. Subjects underwent symptom, neuropsychological, and psychological testing, before and after treatment or control with retesting 2 months after the 40
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.