ArticleMicrobiologyOpen2020
Multilocus sequence typing of Escherichia coli isolates from urinary tract infection patients and from fecal samples of healthy subjects in a college community.
Article in MicrobiologyOpen, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed.
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- Population Ecology-Quantitative Microbial Risk Assessment (QMRA) Model for Antibiotic-Resistant and SusceptibleEnvironmental science & technology · 2025Article
- Ecological dynamics of Enterobacteriaceae in the human gut microbiome across global populations.Nature microbiology · 2025Article
- Challenges and Solutions in Advanced Management of Diabetic Foot Infections: A Review of Recent Studies.Journal of diabetes research · 2025Review
- Molecular characterization of uropathogenicJournal of veterinary science · 2025Article
- Diversity, distribution, and population structure of Escherichia coli in the lower gastrointestinal tract of humans.PloS one · 2025Article
- Analysis of the partial sequencing of clbA, clbB and clbQ in Escherichia coli isolates that produce colibactin and multilocus sequence typing.Scientific reports · 2024Article
- ColiSeq: a multiplex amplicon assay that provides strain level resolution ofMicrobiology spectrum · 2024Article
- Associations between Isolation Source, Clonal Composition, and Antibiotic Resistance Genes inAntibiotics (Basel, Switzerland) · 2024Article
- Genetic features of antimicrobial drug-susceptible extraintestinal pathogenicMicrobiology spectrum · 2024Article
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- First Report of IMI-2-ProducingAntibiotics (Basel, Switzerland) · 2023Article
- Hospital and community wastewater as a source of multidrug-resistant ESBL-producingFrontiers in cellular and infection microbiology · 2023Article
- A One Health Genomic Investigation of Gentamicin Resistance in Escherichia coli from Human and Chicken Sources in Canada, 2014 to 2017.Antimicrobial agents and chemotherapy · 2022Article
- Genomic and Temporal Trends in Canine ExPEC Reflect Those of Human ExPEC.Microbiology spectrum · 2022Article
- A role for ColV plasmids in the evolution of pathogenic Escherichia coli ST58.Nature communications · 2022Article
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Community-acquired urinary tract infections (UTIs) are one of the most common bacterial infections worldwide. Escherichia coli is the most common cause of community-acquired UTI. In general, UTI results from E. coli in the intestine that enters the bladder via the urethra. However, whether these E. coli strains that cause UTI represent members of the intestinal commensal E. coli or a distinct subgroup of pathogenic E. coli remains unestablished. Here, we analyzed E. coli isolates from fecal samples of healthy volunteers and urine samples of UTI patients obtained from a university-affiliated health center. The E. coli isolates were genotyped by multilocus sequence typing (MLST). From May to October 2018, we analyzed 89 E. coli isolates from 76 (75%) rectal swabs from 113 unique healthy volunteers. We also analyzed 106 (27%) E. coli isolates from 398 unique urine samples collected between August and October 2018. Fecal and urine E. coli isolates each contained 31 distinct sequence types (STs). Nine STs were shared by fecal and urine E. coli isolates, which accounted for approximately 50% of urine isolates typed by MLST. Among the shared genotypes, ST10 and ST131 were significantly more frequently found in fecal samples, whereas ST95 and ST127 were significantly more frequently recovered from UTI samples. ST73 was found only among urine samples. These E. coli genotypes clustered and fluctuated over time. These observations suggest that E. coli genotypes found to cause UTI transiently colonize the intestine and that their primary reservoir may reside outside of the human intestine.
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