ArticleCanadian journal of anaesthesia = Journal canadien d'anesthesie2020
The effect of morbid obesity or advanced maternal age on oxytocin-induced myometrial contractions: an in vitro study.
Article in Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01865669 (In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity), which is not on this map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
In-vitro Myometrial Contractility After Oxytocin Pre-exposure in Women With Advanced Maternal Age and Morbid Obesity
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Propranolol and Oxytocin-Induced Contractility in Gravid Human Myometrium: An Ex Vivo Laboratory Study.BJOG : an international journal of obstetrics and gynaecology · 2025Trial
- Oxytocin versus carbetocin at elective Cesarean delivery in parturients with class III obesity: a double-blind randomized controlled noninferiority trial.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025Trial
- Spontaneous and oxytocin-induced contractility of gravid human myometrium with exposure to intravenous anesthetic agents: an ex vivo laboratory study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Article
- Nomogram Predicting Intrapartum Cesarean Delivery in Singleton Pregnancies at Term: A Prospective Observational Study Utilizing an Ultrasound-Based System.International journal of women's health · 2026Article
- Postpartum hemorrhage: risk factors for severe blood loss, surgical intervention and peripartum hysterectomy.Archives of gynecology and obstetrics · 2025Article
- Construction of a predictive model for the risk of postpartum hemorrhage in women with advanced maternal age undergoing natural childbirth.American journal of translational research · 2025Article
- Electroacupuncture and Parecoxib Reduce Inflammatory Injury in a Primary Dysmenorrhea Rat Model: Investigating the Role of the COX-2/NF-κB/NLRP3 Pathway.Journal of pain research · 2025Article
- Association Between Pre-Pregnancy Body Mass Index and Labor Induction Success Rates: A Case Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Maternal Body Mass Index, Myometrium Contractility and Uterotonic Receptor Expression in Pregnancy.Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Oxytocin receptor DNA methylation is associated with exogenous oxytocin needs during parturition and postpartum hemorrhage.Communications medicine · 2023Article
- Regulation of oxytocin-induced calcium transients and gene expression in engineered myometrial tissues by tissue architecture and matrix rigidity.Current research in physiology · 2023Article
- Association of serum leptin at 24-28 weeks gestation with initiation and progression of labor in women.Scientific reports · 2022Article
- Advancing understanding of maternal age: correlating epigenetic clocks in blood and myometrium.Epigenetics communications · 2022Article
- Predicting factors of failed induction of labor in three hospitals of Southwest Ethiopia: a cross-sectional study.BMC pregnancy and childbirth · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate myometrial contractility induced by oxytocin in women with advanced maternal age (AMA) and morbid obesity (MO). We hypothesized that both oxytocin-pretreated and oxytocin-naïve myometrial tissues from women of AMA and women who are MO would exhibit poor myometrial contractility compared with women that are younger and of normal body mass index (BMI).
methodsThis prospective in vitro study was conducted using myometrial samples obtained from women undergoing elective Cesarean deliveries. Three groups of patient were studied: control (≤ 35 yr; BMI, 20-24.9 kg·m
resultsThe MI of contractions was reduced in oxytocin-pretreated samples when compared with their oxytocin naïve counterparts in control (estimated difference -69%; 95% confidence interval [CI], -82 to -48; P < 0.001) and AMA groups (estimated difference, -44%; 95% CI, -68 to -2; P = 0.07). The MI of contractions was not different between oxytocin naïve and oxytocin-pretreated samples from MO women (estimated difference, -26%; 95% CI, -63 to 49; P = 0.46); however, it was significantly lower in these groups compared with oxytocin-naïve samples from the control group.
conclusionsOxytocin pre-treatment reduced myometrial contractility in AMA and control group women compared with their oxytocin-naïve counterparts, as a function of the desensitization phenomenon. Attenuated oxytocin-induced myometrial contractility in MO women in both oxytocin-pretreated and oxytocin-naïve samples suggests that these women have intrinsically reduced uterine contractile ability.
trial registrationwww.clinicaltrials.gov (NCT01865669; registered 28 May, 2013).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.