Evidence map›Paper›PMID 32189127›Full record

ArticleMetabolic brain disease2020

Neostigmine treatment induces neuroprotection against oxidative stress in cerebral cortex of asthmatic mice.

Géssica Luana Antunes, Josiane Silva Silveira, Daniela Benvenutti Kaiber, Carolina Luft, Tiago Marcon Dos Santos, Eduardo Peil Marques, Fernanda Silva Ferreira, Felipe Schmitz, Angela Terezinha de Souza Wyse, Renato Tetelbom Stein and 2 more

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In one paragraph

Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Géssica Luana AntunesLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Josiane Silva SilveiraLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Daniela Benvenutti KaiberLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Carolina LuftLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Tiago Marcon Dos SantosLaboratory of Neuroprotection and Metabolic Disease, Department of Biochemistry, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.
Eduardo Peil MarquesLaboratory of Neuroprotection and Metabolic Disease, Department of Biochemistry, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.
Fernanda Silva FerreiraLaboratory of Neuroprotection and Metabolic Disease, Department of Biochemistry, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.
Felipe SchmitzLaboratory of Neuroprotection and Metabolic Disease, Department of Biochemistry, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.
Angela Terezinha de Souza WyseLaboratory of Neuroprotection and Metabolic Disease, Department of Biochemistry, Federal University of Rio Grande do Sul, UFRGS, Porto Alegre, Brazil.
Renato Tetelbom SteinLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil.
Paulo Márcio PitrezInfant Center, Institutional Research Coordinator, Pontifical Catholic University of Rio Grande do Sul - PUCRS, Hospital Moinhos de Vento, Porto Alegre, Brazil.
Aline Andrea da CunhaLaboratory of Pediatric Respirology, Infant Center, School of Medical, Pontifical Catholic University of Rio Grande do Sul, PUCRS, Porto Alegre, Brazil. alineacunha@hotmail.com.
Pontifícia Universidade Católica do Rio Grande do Sul · BRUniversidade Federal do Rio Grande do Sul · BRHospital Moinhos de Vento · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During chronic inflammatory disease, such asthma, leukocytes can invade the central nervous system (CNS) and together with CNS-resident cells, generate excessive reactive oxygen species (ROS) production as well as disbalance in the antioxidant system, causing oxidative stress, which contributes a large part to neuroinflammation. In this sense, the aim of this study is to investigate the effects of treatment with neostigmine, known for the ability to control lung inflammation, on oxidative stress in the cerebral cortex of asthmatic mice. Female BALB/cJ mice were submitted to asthma model induced by ovalbumin (OVA). Control group received only Dulbecco's phosphate-buffered saline (DPBS). To evaluate neostigmine effects, mice received 80 μg/kg of neostigmine intraperitoneally 30 min after each OVA challenge. Our results revealed for the first time that treatment with neostigmine (an acetylcholinesterase inhibitor that no crosses the BBB) was able to revert ROS production and change anti-oxidant enzyme catalase in the cerebral cortex in asthmatic mice. These results support the communication between the peripheral immune system and the CNS and suggest that acetylcholinesterase inhibitors, such as neostigmine, should be further studied as possible therapeutic strategies for neuroprotection in asthma.

Indexed as

AnimalsAntioxidantsAsthmaBronchoalveolar Lavage FluidCatalaseCerebral CortexCholinesterase InhibitorsFemaleInjections, IntraperitonealMiceMice, Inbred BALB CNeostigmineNeuroprotectionNeuroprotective AgentsOvalbuminOxidative StressAntioxidantsCatalaseCholinesterase InhibitorsNeostigmineNeuroprotective AgentsOvalbuminReactive Oxygen SpeciesSod1 protein, mouseSodium-Potassium-Exchanging ATPaseSuperoxide Dismutase-1Acetylcholinesterase inhibitorAsthmaNeostigmineNeuroprotectionOxidative stress

Identifiers

PMID32189127
OpenAlexW3011732801

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.