ArticleHistochemistry and cell biology2021
Micrometer-resolution X-ray tomographic full-volume reconstruction of an intact post-mortem juvenile rat lung.
Article in Histochemistry and cell biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 33 citations in OpenAlex.
- Evolution of hierarchical phase-contrast tomography on the European Synchrotron beamlines BM05 and BM18: a whole adult human brain imaging case study.Journal of synchrotron radiation · 2026Article
- Accelerating imaging research at large-scale scientific facilities through scientific computing.Journal of synchrotron radiation · 2024Article
- 3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing.Scientific reports · 2024Article
- Phase contrast micro-CT with adjustable in-slice spatial resolution at constant magnification.Physics in medicine and biology · 2024Article
- Feasibility and safety of synchrotron-based X-ray phase contrast imaging as a technique complementary to histopathology analysis.Histochemistry and cell biology · 2023Article
- In focus in HCB.Histochemistry and cell biology · 2023Article
- Article
- Preparation of large biological samples for high-resolution, hierarchical, synchrotron phase-contrast tomography with multimodal imaging compatibility.Nature protocols · 2023Review
- Deep 3D reconstruction of synchrotron X-ray computed tomography for intact lungs.Scientific reports · 2023Article
- The Swiss Light Source and SwissFEL at the Paul Scherrer Institute.European physical journal plus · 2023Article
- TomocuPy - efficient GPU-based tomographic reconstruction with asynchronous data processing.Journal of synchrotron radiation · 2023Article
- Fabrication of a fractal pattern device for focus characterizations of X-ray imaging systems by Si deep reactive ion etching and bottom-up Au electroplating.Applied optics · 2022Article
- Early life exposure to nicotine modifies lung gene response after elastase-induced emphysema.Respiratory research · 2022Article
- Single-Crystalline Perovskite Nanowire Arrays for Stable X-ray Scintillators with Micrometer Spatial Resolution.ACS applied nano materials · 2022Article
- Stereology and three-dimensional reconstructions to analyze the pulmonary vasculature.Histochemistry and cell biology · 2021Review
- Introduction: 3D imaging in lung biology.Histochemistry and cell biology · 2021Article
- Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
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Abstract
In this article, we present an X-ray tomographic imaging method that is well suited for pulmonary disease studies in animal models to resolve the full pathway from gas intake to gas exchange. Current state-of-the-art synchrotron-based tomographic phase-contrast imaging methods allow for three-dimensional microscopic imaging data to be acquired non-destructively in scan times of the order of seconds with good soft tissue contrast. However, when studying multi-scale hierarchically structured objects, such as the mammalian lung, the overall sample size typically exceeds the field of view illuminated by the X-rays in a single scan and the necessity for achieving a high spatial resolution conflicts with the need to image the whole sample. Several image stitching and calibration techniques to achieve extended high-resolution fields of view have been reported, but those approaches tend to fail when imaging non-stable samples, thus precluding tomographic measurements of large biological samples, which are prone to degradation and motion during extended scan times. In this work, we demonstrate a full-volume three-dimensional reconstruction of an intact rat lung under immediate post-mortem conditions and at an isotropic voxel size of (2.75 µm)
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