ArticleJournal of cancer research and clinical oncology2020
Improved survival in metastatic breast cancer: results from a 20-year study involving 1033 women treated at a single comprehensive cancer center.
Article in Journal of cancer research and clinical oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Changes in health behaviors and risk of depression after breast cancer diagnosis and treatment: a nationwide cohort study.Journal of cancer survivorship : research and practice · 2026Article
- International comparisons of survival after recurrent metastatic breast cancer in four countries: A population-based study.Breast (Edinburgh, Scotland) · 2026Article
- Stage IV Breast Cancer Incidence and Survival, 2010-2021.JAMA network open · 2026Article
- Preoperative Function, Previous SERM Treatment, and Triple-Negative Tumor Status are Independently Associated With 3-Month Postoperative Function After Surgical Decompression of Metastatic Breast Cancer.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2025Article
- "Who's gonna take care of my babies?" the impact of children on treatment decisions for women with metastatic breast cancer: a qualitative analysis.BMC cancer · 2025Article
- Factors Associated With Employment and Quality of Working Life in Patients With Metastatic Breast Cancer.Cancer medicine · 2025Article
- Qualitative Findings From a Survey Measuring Informational Needs and Quality of Life of Women Living With Metastatic Breast Cancer.Psycho-oncology · 2025Article
- Six-Month Survivorship Prediction in Spinal Metastatic Patients by Oncologists Shows Reliable Prognostication.Global spine journal · 2025Article
- The Cost-Effectiveness of CDK4/6 Inhibitors in Treating HR+/HER2- Metastatic Breast Cancer Patients in the USA: When Non-medication Expenses are Considered.Clinical drug investigation · 2025Article
- [Staging and systemic treatment of ocular and periocular metastases].Die Ophthalmologie · 2024Review
- Deep neural network provides personalized treatment recommendations forJournal of Cancer · 2024Article
- How to Manage a Patient with Ocular Metastases?Biomedicines · 2022Review
- Overall survival of individuals with metastatic cancer in Sweden: a nationwide study.BMC public health · 2022Article
- Primary-Site Local Therapy for Patients with De Novo Metastatic Breast Cancer: An Educational Review.Annals of surgical oncology · 2022Review
- Article
- Machine learning methods to predict presence of residual cancer following hysterectomy.Scientific reports · 2022Article
- Real-World Breast Cancer Patient Follow-Up Practices by Medical Oncologists in India-A Survey Report.South Asian journal of cancer · 2022Article
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Authors and funding
17 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDiagnosis and treatment of breast cancer have changed profoundly over the past 25 years. The outcome improved dramatically and was well quantified for early stage breast cancer (EBC). However, progress in the treatment of metastatic disease has been less convincingly demonstrated. We have studied survival data of patients with metastatic breast cancer (MBC) from a large academic cancer center over a period of 20 years.
methodsData from 1033 consecutive MBC patients who were treated at the Department of Medical Oncology of the West German Cancer Center from January 1990 to December 2009 were retrospectively analyzed for overall survival (OS) and risk factors. Patients were grouped in 5-year cohorts, and survival parameters of each cohort were compared before and after adjustment for risk factors.
resultsOverall survival of patients with MBC treated at specialized center has significantly improved from 1990 to 2010 (hazard ratio 0.7, 95%CI 0.58-0.84). The increments in OS have become less profound over time (median OS 1990-1994: 24.2 months, 1995-1999: 29.6 months, 2000-2004: 36.5 months, 2005-2009: 37.8 months).
conclusionSurvival of patients with MBC has improved between 1990 and 2004, but less from 2005 to 2009. Either this suggests an unnoticed shift in the patient population, or a lesser impact of therapeutic innovations introduced in the most recent period.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.