Evidence map›Paper›PMID 32189102›Full record

ArticleDigestive diseases and sciences2021

Progression to Cirrhosis Leads to Improvement in Atherogenic Milieu.

Samarth Patel, Mohammad B Siddiqui, Anchalia Chandrakumaran, Viviana A Rodriguez, Masoud Faridnia, Jose Hernandez Roman, Emily Zhang, Michael V Patrone, Genta Kakiyama, Caroline Walker and 8 more

Abstract read
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In one paragraph

Article in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Current Concepts of Cirrhotic Cardiomyopathy.Clinics in liver disease · 2021
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Samarth PatelDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA. patelsamarth@gmail.com.
Mohammad B SiddiquiDivision of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, USA.
Anchalia ChandrakumaranDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, USA.
Viviana A RodriguezDepartment of Biostatistics, Virginia Commonwealth University, Richmond, USA.
Masoud FaridniaDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, USA.
Jose Hernandez RomanDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, USA.
Emily ZhangSchool of Medicine, Virginia Commonwealth University, Richmond, USA.
Michael V PatroneDepartment of Internal Medicine, Virginia Commonwealth University, Richmond, USA.
Genta KakiyamaDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA.
Caroline WalkerDivision of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, USA.
Adam SimaDepartment of Biostatistics, Virginia Commonwealth University, Richmond, USA.
Robert J MinnitiDivision of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, USA.
Sherry BoyettDivision of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, USA.
Jasmohan S BajajDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA.
Arun SanyalDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA.
William M PandakDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA.
Chandra BhatiDivision of Transplant Surgery, Virginia Commonwealth University, Richmond, USA.
Mohammad Shadab SiddiquiDivision of Gastroenterology and Hepatology, Hunter-Holmes McGuire Veterans Affairs Medical Center, Virginia Commonwealth University, Richmond, VA, 23249, USA.
Virginia Commonwealth University · USHunter Holmes McGuire VA Medical Center · US

Funding

BLRD VA I01 BX000197
6 · The paper itself

Abstract

introductionThe prevalence of coronary artery disease (CAD) is high among patients with cirrhosis; however, the impact of it on cardiovascular disease (CVD) is not known. The aim of the current study was to evaluate CVD events in patients with cirrhosis and impact of cirrhosis on biomarkers of atherogenesis.

methodsThe study included 682 patients with decompensated cirrhosis referred for liver transplantation (LT) evaluation between 2010 and 2017. All patients were followed until they experienced a CVD event, non-cardiac death, liver transplantation or last follow-up. To evaluate mechanistic link, patients with NASH cirrhosis were propensity matched 1:2 to non-cirrhosis NASH patients and biomarkers of atherogenic risk were compared.

resultsThe composite CVD outcome occurred in 23(3.4%) patients after a median follow-up period of 585 days (IQR 139, 747). A strong association between presence of any CAD and CVD event was noted (HR = 6.8, 95% CI 2.9, 15.9) that was independent of age, gender, BMI, and MELD score. In competing risk model, the combined rate of LT and non-cardiac was significantly higher when compared to the rate of CVD events. Marker of insulin resistance and inflammation-related markers were similar in patients with and without cirrhosis. Patients with cirrhosis were more likely to have reduced VLDL, sdLDL-C, LDL-C, and triglycerides. Interestingly, patients with cirrhosis had an increase in serum HDL-2, the anti-atherogenic lipoprotein, and adiponectin, a protective serum adipokine.

conclusionThe risk of CVD events in patients with cirrhosis is low and may potentially be due to improvement in markers of atherogenic risk.

Indexed as

Disease ProgressionAtherosclerosisCardiovascular DiseasesCohort StudiesFemaleFollow-Up StudiesHumansInflammation MediatorsLiver CirrhosisLiver TransplantationMaleMiddle AgedNon-alcoholic Fatty Liver DiseaseRetrospective StudiesInflammation MediatorsAtherosclerosisCardiovascular diseaseCirrhosisLipoproteinNonalcoholic steatohepatitis

Identifiers

PMID32189102
OpenAlexW3011346109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.