Evidence map›Paper›PMID 32189000›Full record

ArticleThe Journal of infectious diseases2020

The Application of Cytokine Expression Assays to Differentiate Active From Previously Treated Syphilis.

Noah Kojima, Janet C Siebert, Holden Maecker, Yael Rosenberg-Hasson, Segundo R Leon, Silver K Vargas, Kelika A Konda, Carlos F Caceres, Jeffrey D Klausner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Syphilis-Naive Patients Achieve Treatment Success More Quickly: A Comparison of Time to Syphilis Treatment Success in Patients With Repeat Versus Naive Infection.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Noah KojimaDepartment of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Janet C SiebertCytoAnalytics, Denver, Colorado, USA.
Holden MaeckerHuman Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.
Yael Rosenberg-HassonHuman Immune Monitoring Center, Institute for Immunity, Transplantation, and Infection, Stanford University School of Medicine, Stanford, California, USA.
Segundo R LeonSchool of Medical Technology, Universidad Privada San Juan Bautista, Lima, Peru.
Silver K VargasLaboratory of Sexual Health and Unit of Health, Sexuality and Human Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
Kelika A KondaDepartment of Medicine, University of California Los Angeles, Los Angeles, California, USA.
Carlos F CaceresLaboratory of Sexual Health and Unit of Health, Sexuality and Human Development, Universidad Peruana Cayetano Heredia, Lima, Peru.
Jeffrey D Klausner
Stanford University · USUniversidad Peruana Cayetano Heredia · PEUniversity of California, Los Angeles · USUniversidad Privada San Juan Bautista · PE

Funding

UCLA Rapid, Relevant, Rigorous Implementation Science HubP30MH058107 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAPHAEL J LANDOVITZ · 1997 to 2026
$53.5M
University of California Launching Future Leaders in Global Health Research Training ProgramD43TW009343 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CRAIG R COHEN, Sung-Jae Lee · 2017 to 2026
$14.7M
Syphilis Immunology and Biology to Improve Clinical Management and Vaccine DesignR01AI139265 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jeffrey David Klausner · 2018 to 2026
$4.8M
Syphilis: Translating technology to understand a neglected epidemicR01AI099727 · NIAID · UNIVERSIDAD PERUANA CAYETANO HEREDIA · PI CACERES, CARLOS F. · 2012 to 2016
$1.1M
FIC NIH HHS D43 TW009343NIAID NIH HHS R01 AI099727NIAID NIH HHS R01 AI139265NIMH NIH HHS P30 MH058107
6 · The paper itself

Abstract

To investigate the role of serum cytokine assays to distinguish between active from treated syphilis among serofast patients, we recruited individuals into a prospective cohort study. Participants underwent routine syphilis screening. We selected specimens from a majority cohort of serofast participants with treated and active syphilis. We analyzed specimens with a 62-cytokine multiplex bead-based enzyme-linked immunosorbent assay. Cytokines, brain-derived neurotrophic factor and tumor necrosis factor β, were most predictive. We built a decision tree that was 82.4% accurate, 100% (95% confidence interval, 82%-100%) sensitive, and 45% (18%-75%) specific. Our decision tree differentiated between serum specimens from serofast participants with treated syphilis versus active syphilis.

Indexed as

Anti-Bacterial AgentsBrain-Derived Neurotrophic FactorDecision TreesEnzyme-Linked Immunosorbent AssayHumansLymphotoxin-alphaProspective StudiesSyphilisSyphilis SerodiagnosisTreponema pallidumAnti-Bacterial AgentsBrain-Derived Neurotrophic FactorLymphotoxin-alphaAssayCytokineSyphilis

Identifiers

PMID32189000
PMCPMC7377285
OpenAlexW3010826903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.