ArticleNature2020
Gasdermin E suppresses tumour growth by activating anti-tumour immunity.
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In one paragraph
Article in Nature, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 990 papers.
0numbers the graph read from it
0cells of the map it votes in
990citing papers in PubMed
87.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
990 citing papers in PubMed, 1,683 citations in OpenAlex.
- Development of the rationale of a personalized cancer vaccine based on the in situ vaccine effect of radiotherapy: a mechanistic study of the POLARSTAR trial.Cancer immunology, immunotherapy : CII · 2025Trial
- A four‑gene signature identifies TKI‑induced persister cells and uncovers a ZLN005‑induced pyroptotic vulnerability via the GSDME pathway in EGFR‑mutant lung cancer.Molecular medicine reports · 2026Article
- Next-generation natural killer cell therapy: bench to bedside and beyond.Signal transduction and targeted therapy · 2026Review
- A Biomimetic cRGDyk-Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Generation of DFNA5-deficient chickens reveals a species-specific role of pyroptosis in avian antiviral immunity.Transgenic research · 2026Article
- Tumor gasdermin E acts as a rheostat to limit apoptotic cell survival and mutagenesis in anticancer immune environments.Science advances · 2026Article
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- PhSAN induces PANoptosis via targeting RNF25-mediated endoplasmic reticulum stress.Cell insight · 2026Article
- Article
- Igniting antitumour immunity with cancer cell pyroptosis.Nature reviews. Cancer · 2026Review
- Ferroptosis-Pyroptosis Crosstalk in Spinal Cord Injury: Molecular Mechanisms, Emerging Connectors, and Staged Therapeutic Perspectives.Journal of molecular neuroscience : MN · 2026Review
- Erianin induces GSDMD-dependent pyroptosis and synergistically enhances doxorubicin efficacy via the PI3K/AKT signaling pathway in diffuse large B-cell lymphoma.Chinese medical journal · 2026Article
- Oncolytic virus-delivered GSDME: Unlocking pyroptosis to improve dendritic cell function and amplify cytotoxic T cell response.Molecular therapy. Oncology · 2026Article
- LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma.Journal for immunotherapy of cancer · 2026Article
- Pyroptosis as a novel therapeutic target in glioblastoma multiforme: Mechanisms, molecular insights, and therapeutic potential.Molecular therapy. Nucleic acids · 2026Review
- Activating a novel cell death pathway to target PI-resistant multiple myeloma and enhance immunogenic cell death.Apoptosis : an international journal on programmed cell death · 2026Article
- Pyroptosis-Amplified Decoy Nanovesicles Orchestrate Pyroptotic Antigen Explosion and Endogenous Immune Revitalization for Potentiating Tumour Immunotherapy.Journal of extracellular vesicles · 2026Article
- Targeting Gasdermins for Therapeutic Interventions in Central Nervous System Injury.Neurotoxicity research · 2026Review
- Structural basis of GSDME pore formation and its regulation by S-palmitoylation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review).International journal of molecular medicine · 2026Review
930 more citing papers are in PubMed but not listed here.
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Authors and funding
14 authors at 6 institutions in 5 countries.
Zhibin Zhang *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. zhibin.zhang@childrens.harvard.edu.
Ying Zhang *Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Shiyu XiaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Qing KongDepartment of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
Shunying LiBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Xing LiuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Caroline JunqueiraProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Karla F Meza-SosaProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Temy Mo Yin MokProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
James AnsaraProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Satyaki SenguptaDepartment of Pediatrics, Harvard Medical School, Boston, MA, USA.
Yandan YaoBreast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Hao WuProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Judy LiebermanProgram in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. judy.lieberman@childrens.harvard.edu.
Harvard University · USBoston Children's Hospital · USDana-Farber Cancer Institute · USInstitut Pasteur of Shanghai · CNSun Yat-sen Memorial Hospital · CNSun Yat-sen University · CN
Funding
Elucidating the structural mechanism of pore formation by the (GSDM) Gasdermin familyR01AI139914 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI WU, HAO · 2018 to 2022
$2.6MNIAID NIH HHS R01 AI139914
Abstract
Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)
Indexed as
AnimalsApoptosisAspartic AcidCell Line, TumorFemaleGasderminsGranzymesHumansLoss of Function MutationMiceNeoplasmsPyroptosisReceptors, EstrogenT-Lymphocytes, CytotoxicAspartic AcidGasderminsGranzymesGSDME protein, humanGsdme protein, mouseGZMB protein, humanReceptors, Estrogen
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.