ArticleScientific reports2020
First evidence of anticancer and antimicrobial activity in Mediterranean mesopelagic species.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Antibacterial and anticancer properties of Streptomyces microflavus BA2 isolated from brackish waters.Scientific reports · 2026Article
- In-vitro assessment and characterization of anticancer, antibacterial, and antioxidant activity of diatom-derived metabolites.Scientific reports · 2025Article
- Microbial Interactions between Marine Microalgae and Fungi: From Chemical Ecology to Biotechnological Possible Applications.Marine drugs · 2023Review
- A Treasure of Bioactive Compounds from the Deep Sea.Biomedicines · 2021Review
- Promising Activities of Marine Natural Products against Hematopoietic Malignancies.Biomedicines · 2021Review
- Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Fish Waste: From Problem to Valuable Resource.Marine drugs · 2021Review
- Potential ApproachesFrontiers in oncology · 2021Review
- Chemical Defense in Marine Organisms.Marine drugs · 2020Article
- Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.Antibiotics (Basel, Switzerland) · 2020Review
- Mass Spectrometry Guided Discovery and Design of Novel Asperphenamate Analogs FromFrontiers in microbiology · 2020Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mesopelagic organisms form huge biomass aggregations, supporting important pelagic trophic webs and several top predators. Although some studies on the occurrence, biology and ecology of these organisms are available, to date there are no investigations on their potential use for anticancer and antimicrobial biotechnological applications. The aim of this study was to screen extracts of seven mesopelagic species for possible anticancer (Lung cell line A549, skin cell line A2058, liver cell line HepG2, breast cell line MCF7 and pancreas cell line MiaPaca-2) and antibacterial (Gram-negative bacteria Escherichia coli and Klebsiella pneumoniae, the Gram-positive bacteria methicillin resistant/sensitive Staphylococcus aureus, and Mycobacterium tuberculosis) activities. Results showed that only two species were active, the lanternfish Myctophum punctatum and the Mediterranean krill Meganyctiphanes norvegica. In particular, M. punctatum showed strong activity against the A549 and MCF7 cells, while M. norvegica was more active against HepG2 cells. Regarding antibacterial assays, both species were active against methicillin resistant S. aureus. Fractionation and LC/MS dereplication of the fractions showed that the main compounds found in extracts of both species were EPA, DHA and ETA. For some of the detected compounds anticancer and/or antibacterial activity are already known, but this is the first time that such activities have been found for mesopelagic species.
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