ArticleScientific reports2020
Evaluation of bile salt hydrolase inhibitor efficacy for modulating host bile profile and physiology using a chicken model system.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Intestinal microbiota composition and bile salt hydrolase activity in fast and slow growing broiler chickens: implications for growth performance and production efficiency.Journal of animal science and biotechnology · 2025Article
- Green tea extract complex as a phytogenic supplement to reduce bile salt hydrolase activity and enhance growth performance in weaning pigs.Journal of animal science · 2025Article
- New insights into microbial bile salt hydrolases: from physiological roles to potential applications.Frontiers in microbiology · 2025Review
- Genome-centric investigation of bile acid-metabolizing microbiota in chickens and their association withFrontiers in veterinary science · 2025Article
- Interplay among IL1R1, gut microbiota, and bile acids in metabolic dysfunction-associated steatotic liver disease: a comprehensive review.Journal of gastroenterology and hepatology · 2025Review
- Another renaissance for bile acid gastrointestinal microbiology.Nature reviews. Gastroenterology & hepatology · 2024Review
- Dietary supplementation with mulberry leaf flavonoids and carnosic acid complex enhances the growth performance and antioxidant capacity via regulating the p38 MAPK/Nrf2 pathway.Frontiers in nutrition · 2024Article
- The intestinal microbiome associated with lipid metabolism and obesity in humans and animals.Journal of applied microbiology · 2022Review
- Metabolic control by the microbiome.Genome medicine · 2022Review
- Riboflavin andJournal of animal science and technology · 2022Article
- How to employ metabolomic analysis to research on functions of prebiotics and probiotics in poultry gut health?Frontiers in microbiology · 2022Review
- Characterization of substrate specificity and inhibitory mechanism of bile salt hydrolase from Lactobacillus reuteri CRL 1098 using molecular docking analysis.Biotechnology letters · 2021Article
- Effects of riboflavin and Bacillus subtilis on internal organ development and intestinal health of Ross 708 male broilers with or without coccidial challenge.Poultry science · 2021Article
- Dimethyl Sulfoxide: Morphological, Histological, and Molecular View on Developing Chicken Liver.Toxics · 2021Article
- Improving glucose and lipids metabolism: drug development based on bile acid related targets.Cell stress · 2021Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gut microbial enzymes, bile salt hydrolases (BSHs) are the gateway enzymes for bile acid (BA) modification in the gut. This activity is a promising target for developing innovative non-antibiotic growth promoters to enhance animal production and health. Compelling evidence has shown that inhibition of BSH activity should enhance weight gain by altering the BA pool, host signalling and lipid metabolism. We recently identified a panel of promising BSH inhibitors. Here, we address the potential of them as alternative, effective, non-antibiotic feed additives, for commercial application, to promote animal growth using a chicken model. In this study, the in vivo efficacy of three BSH inhibitors (caffeic acid phenethylester, riboflavin, carnosic acid) were evaluated. 7-day old chicks (10 birds/group) were either untreated or they received one of the specific BSH inhibitors (25 mg/kg body weight) via oral gavage for 17 days. The chicks in treatment groups consistently displayed higher body weight gain than the untreated chicks. Metabolomic analysis demonstrated that BSH inhibitor treatment led to significant changes in both circulating and intestinal BA signatures in support of blunted intestinal BSH activity. Consistent with this finding, liver and intestinal tissue RNA-Seq analysis showed that carnosic acid treatment significantly altered expression of genes involved in lipid and bile acid metabolism. Taken together, this study validates microbial BSH activity inhibition as an alternative target and strategy to antibiotic treatment for animal growth promotion.
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