Evidence map›Paper›PMID 32188715›Full record

Trial reportESMO open2020

Safety, tolerability and clinical implementation of 'ready-to-use'

Prakash Manoharan, Angela Lamarca, Shaunak Navalkissoor, Jose Calero, Pei San Chan, Peter Julyan, Maribel Sierra, Martyn Caplin, Juan Valle

Open access · goldAbstract readClinical Trial, Phase IClinical Trial, Phase IIMulticenter Study
In one paragraph

Trial report in ESMO open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  2. Review
  3. ScalableWorld journal of nuclear medicine · 2026
    Article
  4. Review
  5. [Current radiopharmaceuticals · 2025
    Article
  6. [EJNMMI research · 2023
    Article
  7. Review
  8. Good practices forEJNMMI radiopharmacy and chemistry · 2022
    Review
  9. Review
  10. Cold Kit Labeling: The Future ofFrontiers in medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Prakash ManoharanThe Christie NHS Foundation Trust, ENETS Centre of Excellence, Manchester, UK prakash.manoharan@christie.nhs.uk.ORCID 0000-0002-5155-2310
Angela LamarcaThe Christie NHS Foundation Trust, ENETS Centre of Excellence, Manchester, UK.ORCID 0000-0001-9696-6122
Shaunak NavalkissoorRoyal Free London NHS Foundation Trust, ENETS Centre of Excellence, London, UK.
Jose CaleroThe Christie NHS Foundation Trust, ENETS Centre of Excellence, Manchester, UK.
Pei San ChanRoyal Free London NHS Foundation Trust, ENETS Centre of Excellence, London, UK.
Peter JulyanThe Christie NHS Foundation Trust, ENETS Centre of Excellence, Manchester, UK.
Maribel SierraAdvanced Accelerator Applications USA, New York, New York, USA.
Martyn CaplinRoyal Free London NHS Foundation Trust, ENETS Centre of Excellence, London, UK.
Juan ValleThe Christie NHS Foundation Trust, ENETS Centre of Excellence, Manchester, UK.
Royal Free London NHS Foundation Trust · GBThe Christie NHS Foundation Trust · GBUniversity of Manchester · GBAdvanced Applications (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectivesThis study aimed to assess the safety and tolerability of

methodsA first-in-human phase I/II multicentre, open-label study of a single dose of

resultsTwenty consenting patients were recruited; 14 males, 6 females; mean (SD) age 58 years (12); NET grade 1 (70%), grade 2 (30%); and 75% with stage IV disease. Twelve patients experienced at least one adverse event (AE) during the study with no grade 3-4 toxicities. Only four AEs were classified as possibly (headache (n=1; 4%), nausea (1; 4%)) or probably (dysgeusia (1; 4%), paraesthesia (1; 4%)) related to the study preparation. One hundred thirteen vials of

conclusionsThe new ready-to-use preparation of

Indexed as

FemaleGallium RadioisotopesHumansMaleMiddle AgedNeuroendocrine TumorsOctreotideGallium RadioisotopesOctreotidegalliumimagingneuroendocrinePETSomaKIT-TOC

Identifiers

PMID32188715
PMCPMC7078687
OpenAlexW3011785308

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.